Korean J Radiol.  2011 Jun;12(3):319-326. 10.3348/kjr.2011.12.3.319.

Effects of Propranolol on the Left Ventricular Volume of Normal Subjects During CT Coronary Angiography

• Mo YH
• Jaw FS
• Wang YC
• Jeng CM
• Peng SF

• KMID: 1122329
• DOI: http://doi.org/10.3348/kjr.2011.12.3.319

Abstract

OBJECTIVE
The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography.
MATERIALS AND METHODS
The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF).
RESULTS
The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 +/- 17 and 80 +/- 10 mmHg; 120 +/- 14 and 80 +/- 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 +/- 9.3 and 70.6 +/- 8.9 mL/m2; 23.5 +/- 5.7 and 25.6 +/- 3.7 mL/m2, 66.5 +/- 5.1% and 63.5 +/- 4.6%, respectively).
CONCLUSION
The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.

Keyword

Left ventricular volume; Ejection fraction; Heart rate; Beta-blocker; Propranolol, 64-slice MDCT; CT coronary angiography

MeSH Terms

Adrenergic beta-Antagonists/*administration & dosage
Case-Control Studies
China
Contrast Media/diagnostic use
*Coronary Angiography
Diastole
Electrocardiography
Female
Heart Rate/*drug effects
Humans
Logistic Models
Male
Middle Aged
Propranolol/*administration & dosage
Radiographic Image Interpretation, Computer-Assisted
Systole
*Tomography, X-Ray Computed
Triiodobenzoic Acids/diagnostic use
Ventricular Function, Left/*drug effects

Figure

• 

  Fig. 1 Left ventricular volume of twenty phases' estimation. A. Cardiac axial images were automatically calculated and displayed on workstation. If necessary, we corrected axis by rotating vertical long axis (black solid line) to make axis orthogonal to plane of mitral valve and it passed center of mitral valve and apex. We defined area of interest by designating cardiac apex and concave center of mitral valve on planar images (dash horizontal short lines). B. Nine-slices of short-axis sections and contours of endocardial border of left ventricle were automatically traced and when necessary, traced contours were edited manually. Volume of papillary muscles was included in volume of ventricle.

• 

  Fig. 2 Mean volume-time curve obtained from data of twenty phases' reconstruction. 35-40% and 65-80% phases of R-R interval in males (dash line) and 35-45% and 70-80% phases in females (solid line) showed smallest slope, which indicated least volumetric change.

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