Korean J Gastroenterol.
2004 Jan;43(1):41-46.
Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis
- Affiliations
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- 1Center for Liver Cancer, National Cancer Center, Goyang, Korea.
- 2Department of Internal Medicine, Inje University College of Medicine, Ilsan Paik Hospital, Goyang, Korea.
- 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. yongtkim@plaza.snu.ac.kr
- 4Seoul National University College of Medicine, Liver Research Institute, Seoul, Korea.
Abstract
- BACKGROUND/AIMS: Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis. METHODS: Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced. RESULTS: The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients. CONCLUSIONS: There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
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