Korean J Ophthalmol.  2007 Mar;21(1):18-20. 10.3341/kjo.2007.21.1.18.

Early versus Late Intravitreal Triamcinolone Acetonide for Macular Edema associated with Branch Retinal Vein Occlusion

• Oh JY
• Seo JH
• Ahn JK
• Heo JW
• Chung H

• KMID: 1105025
• DOI: http://doi.org/10.3341/kjo.2007.21.1.18

Abstract

PURPOSE: To compare the effect of early versus late intravitreal injection of triamcinolone in patients with macular edema due to branch retinal vein occlusion (BRVO). METHODS: Twenty eyes of 20 patients with macular edema from BRVO, including 10 with duration after onset of < or =3 months and 10 with duration of >3 months, were treated using a single intravitreal triamcinolone injection (4 mg/0.1 ml). Best-corrected visual acuity and foveal thickness by optical coherence tomography were measured 1, 3, and 6 months post-injection. RESULTS: In patients that received treatment after a disease duration of < or =3 months, visual acuity and foveal thickness significantly improved from baseline over 6 months of follow-up. However, in those with a duration of >3 months, improvements in visual acuity and foveal thickness, though apparent at 1 month, were not maintained at 3 and 6 months post-triamcinolone. CONCLUSIONS: Intravitreal triamcinolone is more effective in patients with BRVO who are treated earlier.

Keyword

Branch retinal vein occlusion; Intravitreal triamcinolone; Macular edema

MeSH Terms

Visual Acuity/drug effects
Triamcinolone Acetonide/*administration & dosage/therapeutic use
Treatment Outcome
Tomography, Optical Coherence
Retinal Vein Occlusion/*complications
Middle Aged
Male
Macular Edema, Cystoid/chemically induced/*drug therapy/physiopathology
Humans
Glucocorticoids/*administration & dosage/therapeutic use
Fovea Centralis/drug effects
Female
Drug Administration Schedule

Figure

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  Fig. 1 LogMAR visual acuity results in the early and late treatment groups. A significant sustained improvement was evident in the early treatment group throughout the subsequent 6-month follow-up, but in the late treatment group, the initial improvement at 1 month was not sustained at 3 and 6 months.

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  Fig. 2 Foveal thickness by optical coherence tomography in the early and late treatment groups. A significant improvement was observed in the early treatment group throughout the 6-month follow-up, but the improvement observed at 1month was not further sustained in the late treatment group.

Reference

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