J Vet Sci.  2006 Mar;7(1):79-81. 10.4142/jvs.2006.7.1.79.

Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury

• Lee JI
• Kim MJ
• Park CS
• Kim MC

• KMID: 1103559
• DOI: http://doi.org/10.4142/jvs.2006.7.1.79

Abstract

Renal ischemia as a course of renal transplantation is a common cause of renal dysfunction as renal failure. The purpose of this study was to investigate the influence of ascorbic acid on blood urea nitrogen (BUN), creatinine (Cr) and resistive index (RI) for dog models with renal ischemia-reperfusion (I/R) injury. Renal ischemia was induced on 6 Beagle dogs. The left kidney was exposed to normothermic ischemia for a short period at 30 min followed by reperfusion. On the blood Cr level and RI, there was no significant difference comparing both groups. 14 days after I/R injury a significant reduction on the blood BUN level was observed in the vehicle group (34.06 mg/dl) compared to that of ischemia induced treated group (10.3mg/dl) (p < 0.05). In conclusion, administration of ascorbic acid for renal ischemic-reperfusion injury had influence on blood BUN level, but it was not revealed the influence on blood Cr and RI.

Keyword

BUN; creatinine; dogs; renal ischemia-reperfusion; resistive index

MeSH Terms

Animals
Antioxidants/*pharmacology
Ascorbic Acid/*pharmacology
Blood Urea Nitrogen
Creatinine/blood
Dog Diseases/*blood/*drug therapy/ultrasonography
Dogs
Kidney Diseases/blood/drug therapy/ultrasonography/*veterinary
Male
Random Allocation
Reperfusion Injury/blood/drug therapy/ultrasonography/*veterinary
Ultrasonography, Doppler, Color/veterinary

Figure

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  Fig. 1 Changes of Cr concentration after renal ischemia-reperfusion of kidneys subjected to 30 min of warm ischemia. The values are expressed as the mean with SD. Pre; Pretreatment period of atropine.

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  Fig. 2 Changes of BUN concentration after renal ischemia-reperfusion of kidneys subjected to 30 min of warm ischemia. The values are expressed as the mean with SD. *Statistically significant difference (p < 0.01) between the both groups. Pre; Pretreatment period of atropine.

• 

  Fig. 3 Changes of resistive index after renal ischemia-reperfusion of kidneys subjected to 30 min of warm ischemia. The values are expressed as the mean with SD. Pre; Pretreatment period of atropine.

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