J Vet Sci.  2004 Mar;5(1):1-3.

Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats

• Dutta BP
• Debnath SC
• Mandal TK
• Chakraborty AK

Abstract

Pharmacokinetics of cefotaxime (50mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0.75mg/kg) was administered intravenously, once daily for five consecutive days to induce kidney damage. The pharmacokinetic variables were calculated in both cases. Kidney damage caused several changes in the determined variables. The Cmax and Cmin of cefotaxime observed at 0.50 and 5 h in normal goats were 24.91+/-1.51 and 1.22+/-0.07 microgram/ml, respectively, while the same in kidney damaged goats at 1 and 72 h were 75.00+/-0.45 and 3.10+/-0.09 microgram/ml, respectively. Renal damage condition significantly increased t1/2,ka (0.48+/-0.01 h), t1/2,ke (20.03+/-0.16 h), AUC (2440.10+/-24.26 microgram. h/ml) and significantly decreased Vdarea (0.59+/-0.007L/kg), Vss (0.58+/-0.007 L/kg) and ClB (0.02+/-0.008 L/kg/h) values of cefotaxime compared to normal goats.

Keyword

pharmacokinetics; cefotaxime; kidney damage; goats

MeSH Terms

Animals
Anti-Bacterial Agents/blood/*pharmacokinetics
Area Under Curve
Cefotaxime/blood/*pharmacokinetics
Female
Goat Diseases/chemically induced/*metabolism
Goats
Half-Life
Injections, Intramuscular
Kidney Failure/chemically induced/*metabolism
Uranyl Nitrate