J Vet Sci.  2006 Jun;7(2):119-122. 10.4142/jvs.2006.7.2.119.

Subcutaneous pharmacokinetics and dosage regimen of cefotaxime in buffalo calves (Bubalus bubalis)

• Sharma SK
• Srivastava AK

• KMID: 1059195
• DOI: http://doi.org/10.4142/jvs.2006.7.2.119

Abstract

The pharmacokinetics and dosage regimen of cefotaxime following its single subcutaneous administration (10 mg/ kg) were investigated in buffalo calves. Plasma and urine samples were collected over 10 and 24 h post administration, respectively. Cefotaxime in plasma and urine was estimated by microbiological assay technique using E. coli as test organism. The pharmacokinetic profiles fitted one-compartment open model. The peak plasma levels of cefotaxime were 6.48 +/- 0.52 microgram/ml at 30 min and the drug was detected upto 10 h. The absorption half-life and elimination halflife were 0.173 +/- 0.033 h and 1.77 +/- 0.02 h, respectively. The apparent volume of distribution and total body clearance were 1.17 +/- 0.10 l/kg and 0.45 +/- 0.03 l/kg/h, respectively. The urinary excretion of cefotaxime in 24 h, was 5.36 +/- 1.19 percent of total administrated dose. A satisfactory subcutaneous dosage regimen for cefotaxime in buffalo calves would be 13 mg/kg repeated at 12 h intervals.

Keyword

buffalo calf; cefotaxime; dosage regimen; pharmacokinetics

MeSH Terms

Animals
Anti-Bacterial Agents/*administration&dosage/blood/*pharmacokinetics/urine
Area Under Curve
*Buffaloes
Cefotaxime/*administration&dosage/blood/*pharmacokinetics/urine
Drug Administration Schedule
Half-Life
Male
Tissue Distribution

Figure

• 

  Fig. 1 Semilogarithmic plot of plasma concentration-time profile of cefotaxime in buffalo calves following a single subcutaneous dose of 10 mg/kg body weight. Values given are mean ± SE of 5 animals.

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