J Vet Sci.  2000 Dec;1(2):113-119.

Teratological effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): induction of cleft palate in the ddY and C57BL/6 mouse

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic halogenated aromatic hydrocarbon, is a teratogen to induce cleft palate when exposed during the pregnancy. There are inter-strain differences in the sensitivity to cleft palate induced by TCDD and other chemicals including polychlorinated terphenyls (PCTs). The C57BL/6 mouse and the ddY mouse had been shown to be different in the induction of cleft palate following the treatment of PCTs, which attempts us to evaluate the TCDD-induced cleft palate in two mouse strains to understand the mechanism through which TCDD and PCTs induce cleft palate. This study evaluated the induction of cleft palate in the fetuses of ddY and C57BL/6 mice after subcutaneous treatment of TCDD on gestation day (GD) 10.5-14.5 or oral treatment on GD 8.5-13.5. Our results clearly showed that ddY mice, a susceptible strain to PCTs-induced cleft palate, are resistant to the induction of cleft palate by TCDD comparably to the high susceptibility of C57BL/6 mice, suggesting a different teratological mechanism between TCDD and PCTs. In addition, at the low doses, our study supported the concept of "window effect" of TCDD on around GD 12 for the induction of cleft palate in C57BL/6 and ddY mice.

Keyword

cleft palate; ddY mouse; 2,3,7,8-tetrachlorodibenzo-p-dioxin

MeSH Terms

Administration, Oral
Animals
Cleft Palate/chemically induced/genetics/pathology/*veterinary
Female
Fetal Diseases/chemically induced/mortality/veterinary
Incidence
Injections, Subcutaneous
Male
Mice
*Mice, Inbred C57BL
Polychloroterphenyl Compounds/toxicity
Pregnancy
Rodent Diseases/*chemically induced/genetics/pathology
Teratogens/*toxicity
Tetrachlorodibenzodioxin/administration & dosage/*toxicity
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