J Korean Med Sci.  2011 Jul;26(7):875-880. 10.3346/jkms.2011.26.7.875.

Detecting the Recurrence of Gastric Cancer after Curative Resection: Comparison of FDG PET/CT and Contrast-Enhanced Abdominal CT

• Kim DW
• Park SA
• Kim CG

• KMID: 1094257
• DOI: http://doi.org/10.3346/jkms.2011.26.7.875

Abstract

The purpose of this study was to evaluate the value of fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for detecting the recurrence of gastric cancer. We performed a retrospective review of 139 consecutive patients who underwent PET/CT and contrast-enhanced abdominal CT (CECT) for surveillance of gastric cancer after curative resection. Recurrence of gastric cancer was validated by histopathologic examination for local recurrence or serial imaging study follow-up with at least 1 yr interval for recurrence of distant metastasis form. Twenty-eight patients (20.1%) were confirmed as recurrence. On the patient based analysis, there was no statistically significant difference in the sensitivity, specificity and accuracy of PET/CT (53.6%, 84.7%, and 78.4%, respectively) and those of CECT (64.3%, 86.5%, and 82.0%, respectively) for detecting tumor recurrence except in detection of peritoneal carcinomatosis. Among 36 recurrent lesions, 8 lesions (22.2%) were detected only on PET/CT, and 10 lesions (27.8%) only on CECT. PET/CT had detected secondary malignancy in 8 patients. PET/CT is as accurate as CECT in detection of gastric cancer recurrence after curative resection, excepting detection of peritoneal carcinomatosis. Moreover, additional PET/CT on CECT could improve detection rate of tumor recurrence and provide other critical information such as unexpected secondary malignancy.

Keyword

Stomach Neoplasms; Recurrence; FDG; PET/CT; Contrast-enhanced Abdominal CT

MeSH Terms

Aged
Female
Fluorodeoxyglucose F18/*diagnostic use
Humans
Male
Middle Aged
Neoplasm Recurrence, Local/*diagnosis/radiography/radionuclide imaging
Positron-Emission Tomography/*methods
Radiopharmaceuticals/*diagnostic use
Retrospective Studies
Sensitivity and Specificity
Stomach Neoplasms/*diagnosis/pathology/surgery
Tomography, X-Ray Computed/*methods

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