Exp Mol Med.
2006 Jun;38(3):241-246.
Expression of hepatitis C virus nonstructural 4B in transgenic mice
- Affiliations
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- 1Laboratory of Human Genomics, Korea Research Institute of Bioscience, and Biotechnology (KRIBB), Daejeon 305-806, Korea. lee10@kribb.re.kr
- 2Department of Pathology and Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk 570-749, Korea.
- 3Department of Pathology, College of Medicine, Chungnam National University, Daejeon 301-131, Korea.
- 4Ilsong Institute of Life Science, Hallym University, Chuncheon 200-702, Korea.
Abstract
- Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.
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