Yonsei Med J.  1961 Dec;2(1):42-47. 10.3349/ymj.1961.2.1.42.

Experimental Production of Arteriosclerosis in Rhesus Monkeys by Deficiency of Pyridoxine Hydrochloride (Vitamin B-6) and Essential Fatty Acids

• Kim DS

• KMID: 1093693
• DOI: http://doi.org/10.3349/ymj.1961.2.1.42

Abstract

Experimental arteriosclerosis that closely resembles human arteriosclerosis was produced by a deficiency of pyridoxine and essential fatty acids in monkeys subjected to a synthetic diet. A detailed analysis of the pathological changes in the various organs disclosed that the changes produced differed in severity as follows: deficiency of both pyridoxine and essential fatty acids produced the most severe changes, then pyridoxine deficiency alone and then essential fatty acids deficiency alone. In view of the data obtained, attention is called to the importance of vitamin B-6 in metabolism, particularly in its relation to protein metabolism and its possible connection to the pathogenesis of human arteriosclerosis. The importance of essential fatty acids also cannot be minimized. Deficiency in both of these two factors certainly appears to be related to the enhancement of arteriosclerosis in monkeys.

MeSH Terms

Humans