Yonsei Med J.
2003 Dec;44(6):968-978. 10.3349/ymj.2003.44.6.968.
Characterization of the Pulmonary Circulation According to Hemodynamic Changes by Computed Tomography
- Affiliations
-
- 1Department of Diagnostic Radiology, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea. kochoe@yumc.yonsei.ac.kr
- 2Research Institute of Radiological Science, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Thoracic Surgery, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Pulmonary Division, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea.
- 5Laboratory Animal Medicine, Medical Research Center, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 1091035
- DOI: http://doi.org/10.3349/ymj.2003.44.6.968
Abstract
- Increased or decreased pulmonary blood flow (PBF) and an increased pulmonary vascular resistance (PVR), represent common and important change in pulmonary hemodynamics. In this study, we constructed 3 hemodynamic models in 5 dogs, that is, an increased and a decreased PBF model, and an increased PVR model. A CT perfusion scan was performed in each hemodynamic model. Perfusion parameters including blood flow (BF), blood volume (BV), mean transit time (MTT), and maximal slope (MS) were calculated automatically by specialized software and analyzed for changes according to hemodynamic status. In terms of the normal state, blood flow was affected by gravity and dependent area showed higher BF and BV and lower MS and MTT than the non-dependent area. The decreased PBF model showed a significant increase in BF and MS (p=0.046, 0.005) but no significant change in BV (p > 0.05), and a slight elongation of MTT (p > 0.05) versus the normal state. The increased PBF model showed a slightly increased BV and a slightly decreased MTT (p > 0.05). The increased PVR model showed significant reduction in BF, BV, and MS (p < 0.000, 0.007, 0.000) and a slight increase in MTT, but without statistical significance (p > 0.05). However, it was noticeable that the distribution of MTT with respect to gravity in the normal lung was completely reversed in the increased PVR model. In conclusion, based on our understanding of perfusion characteristic in normal state, abnormal regional hemodynamic changes in the lung can be detected and evaluated. Predicting changes in pulmonary vascular resistance should be possible by a thorough analysis of CT perfusion parameters.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Spectrum of Multi-Detector Computed Tomography Findings that Alter Pulmonary Artery Diameters in Adults
- Importance of Clinical and Echocardiographic Hemodynamic Assessment in Chronic Pulmonary Embolism
- Hemodynamic Change in Pulmonary Vein Stenosis after Radiofrequency Ablation: Assessment with Magnetic Resonance Angiography
- Vasomotor regulation of the pulmonary circulation
- The Effects of Hemodynamic Findings on Development of Pulmonary Vascular Changes in Patients with Ventricular Septal Defect
