J Vet Sci.
2005 Dec;6(4):353-355.
The anti-thrombotic activity of surfactins
- Affiliations
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- 1College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea. hiyun@cnu.ac.kr
- 2College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.
Abstract
- Platelet aggregation was inhibited and the density of platelet-rich plasma (PRP) clots was decreased by the preincubation of PRP with surfactins, an acidic lipopeptide of Bacillus subtilis complex BC1212 isolated from soybean paste, in dose-dependent manner. Our findings suggest that surfactins are able to prevent a platelet aggregation leading to an inhibition of additional fibrin clot formation, and to enhance fibrinolysis with facilitated diffusion of fibrinolytic agents.
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