Korean J Parasitol.  2008 Jun;46(2):91-93. 10.3347/kjp.2008.46.2.91.

Changes of Serum Adiponectin Levels in Murine Experimental Sparganosis

• Yang HJ

• KMID: 1089469
• DOI: http://doi.org/10.3347/kjp.2008.46.2.91

Abstract

The weight gain phenomenon associated with sparganosis has been well documented and was first recognized n the 1960s. Many studies have been conducted regarding the plerocercoid growth factor in the larva of Spirometra mansoni. n the present study, we hypothesized that the weight gain may be affected by the adipocyte secreted hormones, i.e., diponectin, which is secreted from the adipose tissues in case of tissue migrating parasitic infections. Specifically, we ttempted to ascertain whether the serum levels of adiponectin change in murine sparganosis. However, serum adiponectin levels assayed by ELISA evidenced no significant changes after an experimental infection (P > 0.05). Finally, the weight gain phenomenon in mouse sparganosis is not associated with changes in adiponectin levels, and further investigations involving parasitic infection-induced weight gain remain necessary.

Keyword

Spirometra mansoni; sparganum; sparganosis; adipocyte; adiponectin

MeSH Terms

Adiponectin/*blood
Animals
Disease Models, Animal
Humans
Mice
Mice, Inbred BALB C
Snakes
Sparganosis/blood/*physiopathology
Sparganum/*isolation & purification
*Weight Gain