J Korean Med Sci.  2003 Dec;18(6):791-796. 10.3346/jkms.2003.18.6.791.

The Origin of Proinflammatory Cytokines in Patients with Idiopathic Dilated Cardiomyopathy

• Chang HJ
• Chung J
• Choi BJ
• Choi TY
• Choi SY
• Yoon MH
• Hwang GS
• Shin JH
• Tahk SJ
• Choi BI

• KMID: 1086733
• DOI: http://doi.org/10.3346/jkms.2003.18.6.791

Abstract

Proinflammatory cytokines and their receptors are increased in the peripheral blood of patients with heart failure. We measured cytokines and their receptors in systemic artery (SA), coronary sinus (CS) and infra-renal inferior vena cava (IVC), in order to investigate their origin and influential factors. Thirty patients with idiopathic dilated cardiomyopathy were performed echocardiography at admission, and right heart catheterization after stabilization. Blood was drawn from 3 sites for measurement of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and soluble tumor necrosis factor- receptor (sTNFR) I, II. TNF-alpha at CS (3.25+/-0.34 pg/mL) was higher than those of SA (1.81+/-0.39 pg/mL) and IVC (1.88+/-0.38 pg/mL, p<0.05). IL-6 at CS (18.3+/-3.8 pg/mL) was higher than that of SA (5.8+/-1.2 pg/mL, p<0.01). The levels of sTNFR I, II showed increasing tendency in sequence of SA, IVC and CS. TNF-alpha and sTNFR I, II from all sites were proportional to worsening of functional classes at admission (p<0.05). E/Ea by Doppler study at admission, which reflects left ventricular end-diastolic pressure (LVEDP) was positively correlated with TNF-alpha from SA (R=0.71, p<0.01), CS (R=0.52, p<0.05) and IVC (R=0.46, p<0.05). Thus, elevated LVEDP during decompensation might cause cytokine release from myocardium in patients with idiopathic dilated cardiomyopathy.

Keyword

Heart Failure, Congestive; Cytokines; Myocardial Diseases

MeSH Terms

Adult
Aged
Cardiomyopathy, Congestive/*blood/*immunology
Female
Heart/anatomy & histology
Hemodynamic Processes
Human
Interleukin-6/*blood
Male
Middle Aged
Receptors, Tumor Necrosis Factor/*blood
Statistics
Tumor Necrosis Factor/*metabolism