J Prev Med Public Health.  2006 Nov;39(6):505-510.

The Relationship between ACE I/D Polymorphism and HDL Cholesterol

• You CH
• Hong YS
• Kwak JY
• Kim NY
• Roh MS
• Jung KY
• Lee YH
• Kim JM
• Kim JY

Abstract

OBJECTIVES: The purpose of this study is to evaluate the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with cardiovascular disease risk factors. METHODS: Out of a total of 608 middle-aged adults who visited local health centers, 424 subjects (104 male, 320 female) who had not been diagnosed with hypertension, diabetes mellitus, or hyperlipidemia were included in this study. ACE genotypes were determined in all subjects by polymerase chain reaction methods. RESULTS: Statistical differences in high-density lipoprotein (HDL) cholesterol levels according to ACE genotype were observed using ANOVA (p<0.05), but no differences were found in other cardiovascular risk factors. Specifically, men with the DD and DI genotypes had significantly lower HDL cholesterol levels than those with the II genotype based on the LSD multi-comparison test (p<0.05). CONCLUSIONS: In men, the D-allele of the ACE I/D polymorphism was significantly associated with reduced HDL cholesterol levels. In the future, larger studies are needed to confirm this relationship between ACE I/D polymorphism and HDL cholesterol.

Keyword

Angiotensin converting enzyme 2; Highdensity lipoprotein; Polymorphism

MeSH Terms

Sequence Deletion
Risk Factors
*Polymorphism, Genetic
Peptidyl-Dipeptidase A/*genetics
Mutagenesis, Insertional
Middle Aged
Male
Humans
Health Behavior
Female
Cholesterol, HDL/*blood
Cardiovascular Diseases/genetics/physiopathology