Yonsei Med J.  2000 Oct;41(5):676-679. 10.3349/ymj.2000.41.5.676.

Transient improvement of pyruvate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome: MRS study

• Choi C
• Sunwoo IN
• Kim HS
• Kim DI

• KMID: 1062251
• DOI: http://doi.org/10.3349/ymj.2000.41.5.676

Abstract

Coenzyme Q therapy has been used to support metabolic derangements in patients with mitochondrial encephalomyopathies. Biochemical analysis of the living human brain can be performed by magnetic resonance spectroscopy (MRS). We report upon a KSS patient who was serially imaged with localized proton MRS to monitor the efficacy of CoQ treatment. A 17-year-old girl with KSS was serially imaged with localized proton MRS performed on a GE 1.5 T SIGNA MRI/MRS system. The elevated lactate contents of lesions decreased after one month of CoQ therapy but were re-elevated 10 months after treatment. We conclude that MRS presents us with a powerful tool for monitoring the effects of therapeutic trials in mitochondrial encephalomyopathies.

Keyword

Kearns-Sayre syndrome; MRS; CoQ; lactate

MeSH Terms

Adolescence
Brain/metabolism
Brain/drug effects
Case Report
Female
Human
Kearns Syndrome/metabolism*
Kearns Syndrome/drug therapy*
Kearns Syndrome/diagnosis
Lactic Acid/metabolism
Magnetic Resonance Spectroscopy/diagnostic use*
Pyruvic Acid/metabolism*
Treatment Outcome
Ubiquinone/therapeutic use*