J Korean Med Sci.  1999 Feb;14(1):102-106. 10.3346/jkms.1999.14.1.102.

Negative conversion of antimitochondrial antibody in primary biliary cirrhosis: a case of autoimmune cholangitis

• Cho YJ
• Han DS
• Kim TY
• Jang SJ
• Jeon YC
• Sohn JH
• Lee IH
• Park KN

• KMID: 1062207
• DOI: http://doi.org/10.3346/jkms.1999.14.1.102

Abstract

Autoimmune cholangitis is a clinical constellation of chronic cholestasis, histological changes of chronic nonsuppurative cholangitis and the presence of autoantibodies other than antimitochondrial antibody (AMA). It is uncertain whether this entity is definitely different from AMA positive primary biliary cirrhosis (PBC), though it shows some differences. We report a case of autoimmune cholangitis in a 59-year-old woman, who had been previously diagnosed as AMA-positive PBC associated with rheumatoid arthritis, has been converted to an AMA-negative and anticentromere antibody-positive PBC during follow-up. The response to ursodeoxycholic acid treatment is poor except within the first few months, but prednisolone was dropping the biochemical laboratory data.

Keyword

Cholangitis, autoimmune; Antibodies, antimitochondrial; Liver cirrhosis, biliary; Antibodies, anticentromere

MeSH Terms

Autoantibodies/immunology*
Case Report
Cholangitis/pathology
Cholangitis/immunology*
Female
Human
Liver Cirrhosis, Biliary/pathology
Liver Cirrhosis, Biliary/immunology*
Middle Age
Mitochondria/immunology*