Korean J Gastroenterol.  2022 Jun;79(6):270-273. 10.4166/kjg.2022.048.

Primary Biliary Cholangitis with Ankylosing Spondylitis

• Hong YM
• Yoon KT
• Cho M

• KMID: 2530701
• DOI: http://doi.org/10.4166/kjg.2022.048

Abstract

Primary biliary cholangitis is a chronic inflammatory autoimmune liver disease that is characterized by a positive antimitochondrial antibodies test and progressive destruction of the small intrahepatic bile duct. Ankylosing spondylitis is a chronic, systemic, inflammatory disease of the spine and the sacroiliac joints. The association between these two is very low. This paper reports a rare case who had ankylosing spondylitis and developed primary biliary cholangitis.

Keyword

Primary biliary cholangitis; Spondylitis; ankylosing; Autoimmune diseases

Figure

• 

  Fig. 1 Histology findings of liver biopsies consistent with primary biliary cholangitis. (A) A portal area shows focal lymphoplasma cell aggregates and bile duct damage (hematoxylin and eosin stain, ×200). (B) The immunohistochemistry shows an irregular shape, nuclear stratification, and vacuolar degeneration of the interlobular bile ducts (K7 stain, ×200).

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