Korean J Gastroenterol.  2011 Nov;58(5):258-263. 10.4166/kjg.2011.58.5.258.

The Comparison between 6th and 7th International Union Against Cancer/American Joint Committee on Cancer Classification for Survival Prognosis of Gastric Cancer

• Kim SS
• Choi BY
• Seo SI
• Jung MY
• Choi HS
• Ahn SM
• Choi WH
• Kim HS
• Kim KH
• Jang MK
• Lee JH
• Kim HY
• Shin WG

• KMID: 1026367
• DOI: http://doi.org/10.4166/kjg.2011.58.5.258

Abstract

BACKGROUND/AIMS
The tumor-node-metastasis (TNM) staging is an useful system to assess the prognosis of any solid cancer. As new TNM staging classification of 7th stomach cancer was revised in 2009, we evaluated the prognostic predictability of the 7th International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) TNM classification compared to 6th UICC/AJCC TNM classification in gastric cancer.
METHODS
From January 2000 to December 2009, 5-year survival rates of 266 patients with gastric cancer were calculated by the 6th and 7th UICC/AJCC TNM classification.
RESULTS
Using the 7th UICC/AJCC TNM classification, there was no significant difference in the 5-year cumulative survival rates (5 YSR) between stage IIA and IIB, IIB and IIIA, and IIIA and IIIB (70% vs. 71%, p=0.530; 71% vs. 80%, p=0.703; 80% vs. 75%, p=0.576, respectively) though significant differences of the survival rates were observed among stages of 6th edition. Using T stage of 7th edition, 5 YSR was not different between T2 and T3 (86% vs. 82%, p=0.655). Using N stage of 7th edition, 5 YSR were not different between N1 and N2, N3a and N3b (79% vs. 81%, p=0.506; 41% vs. 17%, p=0.895, respectively).
CONCLUSIONS
The 7th UICC/AJCC TNM classification had poor prognostic predictability in gastric cancer compared to the 6th edition.

Keyword

Neoplasm staging; Stomach neoplasms; Prognosis

MeSH Terms

Adult
Aged
Aged, 80 and over
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
*Neoplasm Staging
Predictive Value of Tests
Prognosis
Retrospective Studies
Stomach Neoplasms/classification/*diagnosis/*mortality/pathology
Survival Rate

Figure

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  Fig. 1. Survival rates according to depth of invasion (T) stage in 6 th (A) and 7 th (B) International Union Against Cancer/American Joint Committee on Cancer (T2 vs. T3, p=0.655). ysr, year survival rate.

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  Fig. 2. Survival rate according to lymph node invasion (N) stage in 6 th (A) and 7 th (B) International Union Against Cancer/American Joint Committee on Cancer (N1 vs. N2, p=0.506; N3a vs. T3b, p=0.895). ysr, year survival rate.

• 

  Fig. 3. Survival rate according to group (TNM) stage in 6 th (A) and 7 th (B) International Union Against Cancer/American Joint Committee on Cancer (IIA vs. IIB, p=0.530; IIB vs. IIIA, p=0.703; IIIA vs. IIIB, p=0.576). ysr, year survival rate.

Reference

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