Korean J Gastroenterol.  2011 Nov;58(5):245-251. 10.4166/kjg.2011.58.5.245.

Study on Association between Single Nucleotide Polymorphisms of MMP7, MMP8, MMP9 Genes and Development of Gastric Cancer and Lymph Node Metastasis

• Kim JH
• Pyun JA
• Lee KJ
• Cho SW
• Kwack KB

• KMID: 1026365
• DOI: http://doi.org/10.4166/kjg.2011.58.5.245

Abstract

BACKGROUND/AIMS
Matrix metallopeptidase (MMP) is known to be involved in tumor invasion and metastasis of cancer. This study investigated the association of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 with gastric cancer (GC) development and lymph node metastasis (LNM).
METHODS
Samples were obtained from 326 chronic gastritis (CG) and 153 GC patients and genotyped by using the GoldenGate(R) method. Chi-square test was performed to identify the difference of allele distribution between each group (CG vs. GC; CG vs. with LNM GC). The associations of genotype with risk of GC and LNM were estimated by odds ratio and the 95% confidence interval was calculated by logistic regression adjusting for age and sex.
RESULTS
The allele and genotype frequencies of MMP7 rs11568818, MMP8 rs11225395, MMP9 rs17576 and rs2250889 were not associated with the development of GC and LNM.
CONCLUSIONS
In summary, MMP7 rs11568818, MMP8 rs11225395 MMP9 rs17576 and rs2250889 were not associated with the GC development and LNM in Korean population.

Keyword

Stomach neoplasms; Lymph node metastasis; Metalloproteinase 7; Metalloproteinase 8; Metalloproteinase 9

MeSH Terms

Adult
Age Factors
Aged
Alleles
Chronic Disease
Female
Genotype
Humans
Logistic Models
Lymphatic Metastasis
Male
Matrix Metalloproteinase 7/*genetics
Matrix Metalloproteinase 8/*genetics
Matrix Metalloproteinase 9/*genetics
Middle Aged
Neoplasm Staging
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Sex Factors
Stomach Neoplasms/*genetics