Korean J Intern Med.  2011 Sep;26(3):340-347. 10.3904/kjim.2011.26.3.340.

Efficacy and Safety of Monthly 150 mg Oral Ibandronate in Women with Postmenopausal Osteoporosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

• Lee YH
• Song GG

• KMID: 1022174
• DOI: http://doi.org/10.3904/kjim.2011.26.3.340

Abstract

BACKGROUND/AIMS
The aim of this study was to assess the efficacy and safety of monthly oral 150 mg ibandronate in women with postmenopausal osteoporosis (PMO).
METHODS
A systematic review and meta-analysis were performed to determine treatment efficacy and safety outcomes between monthly oral 150 mg ibandronate and weekly 70 mg alendronate, daily 2.5 mg ibandronate, and a placebo.
RESULTS
Eight randomized controlled trials were included in this systematic review and meta-analysis. Once-monthly 150 mg ibandronate therapy was clinically comparable to weekly 70 mg alendronate, showing increased bone mineral density (BMD) in both the lumbar spine and total hip. Pooled data from two cross-over trials showed that significantly more women with PMO preferred once-monthly ibandronate therapy to once-weekly alendronate therapy (relative risk [RR], 2.422; 95% confidence interval [CI], 2.111 to 2.825; p < 1 x 10(-8)) and found the monthly ibandronate regimen more convenient than the weekly alendronate regimen (RR, 3.096; 95% CI, 2.622 to 3.622; p < 1 x 10(-8)). Monthly 150 mg ibandronate therapy resulted in a significantly higher change in BMD of the lumbar spine than with the placebo. A once monthly 150 mg regimen produced greater increases in lumbar spine, total hip, femoral neck, and trochanter BMD than daily treatment, with a similar incidence of adverse events between the groups.
CONCLUSIONS
Once monthly 150 mg ibandronate therapy was clinically comparable to weekly 70 mg alendronate, and patients strongly preferred the convenience of monthly ibandronate over weekly alendronate. Monthly 150 mg ibandronate was superior to, and as well tolerated as, the daily treatment.

Keyword

Ibandronic acid; Efficacy; Safety; Osteoporosis; Review

MeSH Terms

Administration, Oral
Alendronate/administration & dosage
Bone Density/drug effects
Bone Density Conservation Agents/*administration & dosage/adverse effects
Bone and Bones/drug effects/radiography
Diphosphonates/*administration & dosage/adverse effects
Drug Administration Schedule
Evidence-Based Medicine
Female
Humans
Osteoporosis, Postmenopausal/*drug therapy/radiography
Patient Preference
Randomized Controlled Trials as Topic
Time Factors
Treatment Outcome