- Rho-Associated Kinase 2 Polymorphism of Vasospastic Angina in Korean Population
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Park CS
- KMID: 1433856
- Korean Circ J.
- 2012 Jun;42(6):379-381.
- doi: 10.4070/kcj.2012.42.6.379
No abstract available. -
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- Rho-kinase and Insulin Signaling
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Kim YB
- KMID: 2177593
- J Korean Diabetes Assoc.
- 2006 Jul;30(4):237-245.
- doi: 10.4093/jkda.2006.30.4.237
Insulin's ability to acutely stimulate glucose uptake and metabolism in peripheral tissues is essential for normal glucose homeostasis. Resistance to this insulin effect is a major pathogenic feature of type... -
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- Role of Rho-Kinase Activity in Angiotensin II-Induced Contraction of Corpus Cavernosum Smooth Muscle in the Rabbit
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Kim MK, Park JK
- KMID: 2145847
- Korean J Androl.
- 2003 Apr;21(1):32-37.
PURPOSE: RhoA/Rho-kinase regulates vascular tone via a calcium sensitization mechanism. Stimulation of the AT1 receptor by angiotensin (ANG) II activates the Rho A/Rho-kinase signaling pathway. However, its role in corpus... -
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- Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition
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Je HD, Jeong JH
- KMID: 2150475
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):69-74.
- doi: 10.4196/kjpp.2016.20.1.69
The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used... -
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- Effects of Rho Kinase Inhibitor on Detrusor Overactivity after Bladder Outlet Obstruction in Rats
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Kim HW, Cho SY, Park DJ, Yoon BI, Lee JY
- KMID: 2061277
- Korean J Urol.
- 2007 Aug;48(8):832-837.
- doi: 10.4111/kju.2007.48.8.832
PURPOSE: A partial bladder outlet obstruction(PBOO) related detrusor hypertrophy is associated with up-regulation of the Rho kinase activity in an experimental animal model, and has been implicated in PBOO induced... -
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- Prevention of Vasculogenic Erectile Dysfunction in Rat Model by the Chronic Administration of Oral Rho Kinase Inhibitor
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Park K, Park MY, Kim SW, Paick JS
- KMID: 2294182
- Korean J Urol.
- 2006 Mar;47(3):322-330.
- doi: 10.4111/kju.2006.47.3.322
PURPOSE: Since Rho-Rho kinase calcium sensitizing pathway is being regarded as a potential target not only for the treatment of erectile dysfunction but also atherosclerosis, we designed a study to... -
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- The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle
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Min CH, Wang Y, Bae J, Han JH, Sohn UD
- KMID: 2285593
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):473-478.
- doi: 10.4196/kjpp.2015.19.5.473
To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide,... -
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- Change in Expression of Rho-kinase and Nitric Oxide Synthase in Penile Tissue of Rats Under Stress
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Kim KH, Yoon H
- KMID: 2226562
- Korean J Androl.
- 2008 Sep;26(3):130-135.
PURPOSE: The autonomic nervous system (ANS) and stress hormones are important mediators in the stress response. The ANS controls the tone of corpus cavernosal smooth muscle. Clinically, it is not... -
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- Effect of Rho Kinase Inhibitor on the Production of Nitric Oxide in Trabecular Meshwork Cells
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Kim JW, Kim KH, Hwang SJ
- KMID: 2212801
- J Korean Ophthalmol Soc.
- 2016 Apr;57(4):650-656.
- doi: 10.3341/jkos.2016.57.4.650
PURPOSE: To investigate the effects of Rho kinase (ROCK) inhibitor on the production of nitric oxide (NO) and expression of endothelial nitric oxide synthase (eNOS) in cultured human trabecular meshwork... -
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- Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
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Baek I, Jeon SB, Song MJ, Yang E, Sohn UD, Kim IK
- KMID: 2071672
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):201-207.
- doi: 10.4196/kjpp.2009.13.3.201
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular... -
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- Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue
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Yoon H, Lee D, Chun K, Yoon H, Yoo J
- KMID: 2314813
- Korean J Urol.
- 2010 Feb;51(2):132-138.
PURPOSE: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation. MATERIALS AND METHODS: A total of 48 female Sprague-Dawley... -
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- Calcium Sensitization Induced by Sodium Fluoride in Permeabilized Rat Mesenteric Arteries
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Yang E, Cho JY, Sohn UD, Kim IK
- KMID: 1457701
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):51-57.
- doi: 10.4196/kjpp.2010.14.1.51
It was hypothesized that NaF induces calcium sensitization in Ca2+-controlled solution in permeabilized rat mesenteric arteries. Rat mesenteric arteries were permeabilized with beta-escin and subjected to tension measurement. NaF potentiated... -
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- Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Sohn UD, La HO
- KMID: 2170541
- Biomol Ther.
- 2016 Jan;24(1):57-61.
- doi: 10.4062/biomolther.2015.104
Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of... -
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- Hypothermia Inhibits Endothelium-Independent Vascular Contractility via Rho-kinase Inhibition
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Chung YH, Oh KW, Kim ST, Park ES, Je HD, Yoon HJ, Sohn UD, Jeong JH, La HO
- KMID: 2429053
- Biomol Ther.
- 2018 Mar;26(2):139-145.
- doi: 10.4062/biomolther.2016.233
The present study was undertaken to investigate the influence of hypothermia on endothelium-independent vascular smooth muscle contractility and to determine the mechanism underlying the relaxation. Denuded aortic rings from male... -
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- The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Kim HD, La HO
- KMID: 2380332
- Biomol Ther.
- 2015 May;23(3):233-237.
- doi: 10.4062/biomolther.2014.148
Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin... -
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- Endothelium Independent Effect of Pelargonidin on Vasoconstriction in Rat Aorta
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Min YS, Yoon HJ, Je HD, Lee JH, Yoo SS, Shim HS, Lee HY, La HO, Sohn UD
- KMID: 2420388
- Biomol Ther.
- 2018 Jul;26(4):374-379.
- doi: 10.4062/biomolther.2017.197
In this study, we investigated the effects of pelargonidin, an anthocyanidin found in many fruits and vegetables, on endothelium-independent vascular contractility to determine the underlying mechanism of relaxation. Isometric contractions... -
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- The Effect of Stress on Bladder Stability
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Kim KH, Yoon H
- KMID: 1997089
- Korean J Urol.
- 2007 Nov;48(11):1131-1138.
- doi: 10.4111/kju.2007.48.11.1131
PURPOSE: This study was designed to examine the effect of stress on the pathophysiology of bladder stability via the Rho-kinase and nitric oxide synthase activity, which are required for muscle... -
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- The Inhibitory Effect of Eupatilin on the Agonist-Induced Regulation of Vascular Contractility
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Je HD, Kim HD, Jeong JH
- KMID: 1432760
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):31-36.
- doi: 10.4196/kjpp.2013.17.1.31
The present study was undertaken to investigate the influence of eupatilin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used... -
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- The Inhibitory Effect of Apigenin on the Agonist-Induced Regulation of Vascular Contractility via Calcium Desensitization-Related Pathways
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Je HD, Kim HD, La HO
- KMID: 2170648
- Biomol Ther.
- 2014 Mar;22(2):100-105.
Apigenin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of... -
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- New classes of glaucoma medical treatment
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Choi JA
- KMID: 2459159
- J Korean Med Assoc.
- 2019 Sep;62(9):497-504.
- doi: 10.5124/jkma.2019.62.9.497
Glaucoma is a progressive degenerative disease of the optic nerve head, characterized by a specific pattern of axonal loss and visual field deterioration. This review aims at introducing the different... -
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