- The Effect of Oral Administration of Black Sticky Rice with Giant Embryo on Brain GABA Concentrations
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Jung WY, Kim SG, Kim HK, Huh SY, Kim DW, Yoon DU, Yang CH, Kim HY, Jang EY
- KMID: 2456172
- Psychiatry Investig.
- 2019 Aug;16(8):615-620.
- doi: 10.30773/pi.2019.05.13.2
OBJECTIVE: Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is... -
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- Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G(αs) Protein-coupled Receptor
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Lee N, Sa M, Hong YR, Lee CJ, Koo J
- KMID: 2424731
- Exp Neurobiol.
- 2018 Oct;27(5):365-376.
- doi: 10.5607/en.2018.27.5.365
Medium-chain fatty acids (MCFAs) are mostly generated from dietary triglycerides and can penetrate the blood-brain barrier. Astrocytes in the brain use MCFAs as an alternative energy source. In addition, MCFAs... -
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- Safety and Efficacy of Gamma-Aminobutyric Acid from Fermented Rice Germ in Patients with Insomnia Symptoms: A Randomized, Double-Blind Trial
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Byun JI, Shin YY, Chung SE, Shin WC
- KMID: 2415043
- J Clin Neurol.
- 2018 Jul;14(3):291-295.
- doi: 10.3988/jcn.2018.14.3.291
BACKGROUND AND PURPOSE: This study aimed to determine the subjective and objective improvements in sleep quality after treatment with gamma-aminobutyric acid (GABA; 300 mg daily) extracted from unpolished rice germ. METHODS:... -
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- Astrocytic proBDNF and Tonic GABA Distinguish Active versus Reactive Astrocytes in Hippocampus
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Chun H, An H, Lim J, Woo J, Lee J, Ryu H, Lee CJ
- KMID: 2416243
- Exp Neurobiol.
- 2018 Jun;27(3):155-170.
- doi: 10.5607/en.2018.27.3.155
Astrocytes are the most abundant cell type in the brain and they make close contacts with neurons and blood vessels. They respond dynamically to various environmental stimuli and change their... -
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- Decreased Glial GABA and Tonic Inhibition in Cerebellum of Mouse Model for Attention-Deficit/Hyperactivity Disorder (ADHD)
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Kim YS, Woo J, Lee CJ, Yoon BE
- KMID: 2389007
- Exp Neurobiol.
- 2017 Aug;26(4):206-212.
- doi: 10.5607/en.2017.26.4.206
About 5~12% of school-aged children suffer from the Attention-Deficit/Hyperactivity Disorder (ADHD). However, the core mechanism of ADHD remains unclear. G protein-coupled receptor kinase-interacting protein-1 (GIT1) has recently been reported to... -
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- In Silico Model-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology
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Agrawal R, Kalmady SV, Venkatasubramanian G
- KMID: 2378479
- Clin Psychopharmacol Neurosci.
- 2017 May;15(2):115-125.
- doi: 10.9758/cpn.2017.15.2.115
OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate... -
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- Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of Rehmannia glutinous can be Mediated through GABA Receptor-chloride Channel Complexes
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Kim M, Kim HJ, Kim SM, De la Peña JB, Dela Peña IJ, Botanas CJ, Woo T, Lee YS, Ryu JH, Cheong JH
- KMID: 2376498
- Nat Prod Sci.
- 2017 Mar;23(1):40-45.
- doi: 10.20307/nps.2017.23.1.40
Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs... -
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- Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat
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Lee KJ, Shim I, Sung JH, Hong JT, Kim IS, Cho CB
- KMID: 2374874
- J Korean Neurosurg Soc.
- 2017 Feb;60(2):138-145.
- doi: 10.3340/jkns.2016.0202.020
OBJECTIVE: High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson’s disease. However, the neurochemical basis of its effects remains unknown. The... -
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- Effect of Low and High-Dose GABA from Unpolished Rice-Germ on Timing and Quality of Sleep: A Randomized Double-Blind Placebo-Controlled Trial
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Shin YY, Byun JI, Chung SE, Seong MJ, Cho HA, Cha HK, Shin WC
- KMID: 2405604
- J Sleep Med.
- 2016 Dec;13(2):60-66.
- doi: 10.13078/jsm.16011
OBJECTIVES: Gamma-aminobutyric acid (GABA) has potential benefits in counteracting the sleep disruption and potential therapeutic effects on blood pressure, stress, cancer, and inflammatory diseases. Recently, High-dose GABA can be extracted... -
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- Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model
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Yarishkin , Lee J, Jo S, Hwang EM, Lee CJ
- KMID: 2165557
- Exp Neurobiol.
- 2015 Sep;24(3):211-218.
- doi: 10.5607/en.2015.24.3.211
Like neurons, astrocytes produce and release GABA to influence neuronal signaling. At the perforant path to dentate gyrus granule neuron synapse, GABA from astrocyte was found to be a strong... -
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- Differential Role of Central GABA Receptors in Nociception of Orofacial Area in Rats
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Lee AR, Lim NH, Kim HJ, Kim MJ, Ju JS, Park MK, Lee MK, Yang KY, Ahn DK
- KMID: 2068541
- Int J Oral Biol.
- 2015 Sep;40(3):117-125.
- doi: 10.11620/IJOB.2015.40.3.117
The present study investigated the role of central GABA(A) and GABA(B) receptors in orofacial pain in rats. Experiments were conducted on Sprague-Dawley rats weighing between 230 and 280 g. Intracisternal... -
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- Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice
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Mabunga DF, Gonzales E, Kim HJ, Choung SY
- KMID: 2380337
- Biomol Ther.
- 2015 May;23(3):268-274.
- doi: 10.4062/biomolther.2015.022
gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian central nervous system, is involved in sleep physiology. Caffeine is widely used psychoactive substance known to induce wakefulness and insomnia... -
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- Attenuated Glial K+ Clearance Contributes to Long-Term Synaptic Potentiation Via Depolarizing GABA in Dorsal Horn Neurons of Rat Spinal Cord
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Lee J, Favorov OV, Tommerdahl M, Lee CJ, Whitsel BL
- KMID: 2009025
- Exp Neurobiol.
- 2014 Mar;23(1):53-64.
- doi: 10.5607/en.2014.23.1.53
It has been reported that long-term enhancement of superficial dorsal horn (DHs) excitatory synaptic transmission underlies central sensitization, secondary hyperalgesia, and persistent pain. We tested whether impaired clearance of K+... -
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- The Changes in the Expression of gamma-Aminobutyric Acid Related Enzymes in the Mouse Hippocampus Following Ketogenic Diet
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Noh HS, Kwon OY, Yun HJ, Kang SS, Cho GJ, Choi WS
- KMID: 2224461
- Korean J Anat.
- 2007 Sep;40(3):219-225.
The ketogenic diet (KD) has been used to treat intractable childhood epilepsy. However, its mechanism of action remains unknown. In the present study, we examined the effects of KD on... -
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- GABA Receptor Imaging
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Lee JD
- KMID: 2313037
- Nucl Med Mol Imaging.
- 2007 Apr;41(2):166-171.
GABA is primary an inhibitory neurotransmitter that is localized in inhibitory interneurons. GABA is released from presynaptic terminals and functions by binding to GABA receptors. There are two types of... -
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- High K-induced Epileptiform Activity under GABA Antagonist and Carbamazepine in the Rat Visual Cortex
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Choi BJ
- KMID: 2329335
- J Korean Child Neurol Soc.
- 2006 May;14(1):16-23.
PURPOSE: The goal of this study was to investigate the effect of increase of K on the excitability of the visual cortex under GABA antagonist, carbamazepine(CBZP), 6-cyano-7-nitroquinoxaline-dione disodium(CNQX) and D-(-)-2-amino-5-phosphonopentanoic... -
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- Effects of Zinc on Spontaneous Miniature GABA Release in Rat Hippocampal CA3 Pyramidal Neurons
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Choi BJ, Jang IS
- KMID: 2071621
- Korean J Physiol Pharmacol.
- 2006 Apr;10(2):59-64.
The effects of Zn2+ on spontaneous glutamate and GABA release were tested in mechanically dissociated rat CA3 pyramidal neurons which retained functional presynaptic nerve terminals. The spontaneous miniature excitatory and... -
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- Alterations of Glutamate and GABA Immunoreactivities in the Anterior Horn of the Ischemic Spinal Cord of the Rabbit
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Song KW, Park IH, Won MH, Song YS, Lee SY, Oh WS, Park JY, Choi DE
- KMID: 2399130
- J Korean Orthop Assoc.
- 2004 Oct;39(6):589-597.
PURPOSE: This study was carried out to investigate chronological changes of glutamate and gamma-aminobutyric acid (GABA) immunoreactivities in the anterior horn of the spinal cord after ischemia-reperfusion. MATERIALS AND METHODS:... -
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- Neuronal Excitatory Action of GABA on the Pelvic Ganglia
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Gill SB, Cha SK, Kim DR, Jang SG, Jang YK, Kong ID
- KMID: 1822221
- J Korean Neurosurg Soc.
- 2004 Aug;36(2):145-149.
OBJECTIVE: In the central nervous system, gamma-aminobutyric acid (GABA) is well known to act as an inhibitory neurotransmitter by hyperpolarizing postsynaptic neurons through gating GABA-activated Cl- channels. To date, however,... -
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- A Role of Glutamate and GABA Receptors in the Generation of Formalin-induced Impulse Firing of Spinal Dorsal Horn Neurons in the Rat
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Bae JY, Jang JH, Jeon YH, Yoon DM, Leem JW, Nam TS, Paik KS
- KMID: 2199679
- J Korean Pain Soc.
- 2003 Dec;16(2):118-132.
BACKGROUND: A peripheral subcutaneous injection of formalin produces biphasic impulse firing of the spinal nociceptive neurons. The roles of excitatory glutamatergic and inhibitory GABAergic receptors were investigated in the formalin-induced... -
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