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Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots

Yin J, Heo SI, Wang MH

This study investigated the antioxidant activity of methanol (MeOH) and water extracts from roots of Cirsium japonicum in vitro. MeOH extract showed a stronger free radical scavenging activity than water...
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Clinical improvement in a case of atypical infantile onset Pompe disease with enzyme replacement therapy

Jeon YH, Eun BL, Son CS, Lee DH

Pompe disease is a genetic disorder caused by a deficiency of acid alpha-glucosidase (GAA). Infantile onset Pompe disease is uniformly lethal. Affected infants generally present in the first few months...
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New therapeutic agents for glycemic control in diabetes mellitus

Kwon HS

A recent report from International Diabetes Federation estimates that 366 million people have diabetes in 2011 and this will have risen to 552 million by 2030. That means one adult...
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Need for Diabetes Prevention Study

Jeon JY, Kim DJ

In Korea, diabetes mellitus, which causes micro and macrovascular complications, has been rapidly increasing during recent decades and has become a leading cause of disability-adjusted life years. The prevalence of...
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Treatment with alpha-glucosidase inhibitor for severe reactive hypoglycemia: A case report

Lee HC, Jeong SS, Lee WY, Jeong HS, Lee SS

  • KMID: 2252848
  • Korean J Med.
  • 2002 Sep;63(3):335-339.
Gastrectomy or vagotomy may result in reactive hypoglycemia, which, in some cases, can reduce the plasma glucose levels to 30~40 mg/dL due to rapid digestion and absorption of food, especially...
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Use of Oral Hypoglycemic Agents in Type 2 Diabetic Patients with Hepatic Dysfunction

Lee KY

The prevalence of type 2 diabetes mellitus in the Korea has increased dramatically over the past decade. Clinicians can prescribe the following six currently available classes of oral hypoglycemic agents:...
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Production and Characterization of a New alpha-Glucosidase Inhibitory Peptide from Aspergillus oryzae N159-1

Kang MG, Yi SH, Lee JS

An alpha-glucosidase inhibitor was developed from Aspergillus oryzae N159-1, which was screened from traditional fermented Korean foods. The intracellular concentration of the inhibitor reached its highest level when the fungus...
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A case of postprandial hypotension presenting with postprandial dizziness

Kim SK, Noh KH

  • KMID: 2258790
  • Korean J Med.
  • 2008 Sep;75(3):358-361.
Postprandial hypotension is an important minor clinical problem. It is a common disorder that causes unexplained dizziness, falls, lightheadedness, syncope, angina pectoris, and even transient ischemic attacks of the brain....
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Juvenile Pompe Disease with CNS Involvement: A Case Report

Kwon T, Lee SY

  • KMID: 1928128
  • Korean J Leg Med.
  • 2003 May;27(1):92-95.
Pompe disease (Glycogenosis type 2) is an autosomal recessive glycogen storage disorder by deficiency of lysosomal acid alpha-glucosidase. The disorder encompasses a range of phenotypes, each including myopathy but differing...
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The Enzymatic Approach of Zygomycosis - Causing Mucorales

Ko HS, Taguchi H, Takizawa K, Fukusima K, Kim HS

  • KMID: 1513576
  • Korean J Med Mycol.
  • 2007 Mar;12(1):9-17.
Various oxidases and hydrolytic enzymes were analyzed to investigate the relationship between these enzymes and the skin pathogenicity of 18 Mucorales strains. Each strain was cultured in a nutrient medium...
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In vitro biological evaluation of 100 selected methanol extracts from the traditional medicinal plants of Asia

Li C, Wang MH

  • KMID: 2313723
  • Nutr Res Pract.
  • 2014 Apr;8(2):151-157.
BACKGROUND/OBJECTIVES: In Asia, various medicinal plants have been used as the primary sources in the health care regimen for thousands of years. In recent decades, various studies have investigated the...
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The ingredients in Saengshik, a formulated health food, inhibited the activity of alpha-amylase and alpha-glucosidase as anti-diabetic function

Kim M, Kim E, Kwak HS, Jeong Y

BACKGROUND/OBJECTIVES: We investigated total 26 ingredients of Saengshik which will be commercially produced as an anti-diabetic dietary supplement. SUBJECTS/METHODS: Thirteen vegetables, nine cereals, three legumes and one seed were extracted with...
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Effects of Sasa Borealis Leaf Extract on the Glucose Tolerance of Major Foods for Carbohydrate

Yun EK, Heo YR, Lim HS

Sasa borealis leaf has been known to have anti-diabetic properties. In this study, we tried to evaluate the effects of Sasa borealis leaf extract (SBE) on the inhibition of alpha-glucosidase...
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A Case of Suspected Danon Disease Presenting as a Hypertrophic Cardiomyopathy

Park SY, Park DG, Choi HH, Yoon DH, Kim SE, Lee JH, Han KR, Oh DJ

Danon disease is characterized clinically by the triad of cardiomyopathy, myopathy and mental retardation. It was originally reported as a lysosomal glycogen storage disease with normal acid maltase by Danon....
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Nutritional Considerations for Diabetic Patients on Diabetes Medication

Ju DL

Individuals who have diabetes should receive individualized medical nutrition therapy (MNT) based on an assessment of the individual's current eating patterns, preferences, and metabolic goals. The dietician should be able...
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Antihyperglycemic agent combination therapy for patients with type 2 diabetes mellitus

Lee JM

Type 2 diabetes mellitus and diabetic complications have sharply increased and have become an important issue to resolve. The goal of treatment of type 2 diabetes is to prevent the...
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Glycogen Storage Disease Type II: A Case Report

Moon JL, Kang SY, Yang SH, Choe SJ, Lee YS

  • KMID: 2174941
  • J Korean Acad Rehabil Med.
  • 1997 Dec;21(6):1224-1230.
Glycogen Storage Disease Type II is caused by the deficiency of acid maltase resulting in lysosomal accumulation of glycogen. There are two major clinical syndromes, a severe generalized and invariable...
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Inhibitory activity of Euonymus alatus against alpha-glucosidase in vitro and in vivo

Lee SK, Hwang JY, Song JH, Jo JR, Kim MJ, Kim ME, Kim JI

  • KMID: 2313312
  • Nutr Res Pract.
  • 2007 Sep;1(3):184-188.
The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood...
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Study of the mechanisms underlying increased glucose absorption in Smilax china L. leaf extract-treated HepG2 cells

Kang YH, Kim DJ, Kim KK, Lee SM, Choe M

  • KMID: 2327149
  • J Nutr Health.
  • 2014 Jun;47(3):167-175.
PURPOSE: Previous studies have shown that treatment with Smilax china L. leaf extract (SCLE) produces antidiabetic effects due to alpha-glucosidase inhibition. In this study, we examined the mechanism underlying these...
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Comparison of antioxidant, alpha-glucosidase inhibition and anti-inflammatory activities of the leaf and root extracts of Smilax china L.

Kim KK, Kang YH, Kim DJ, Kim TW, Choe M

  • KMID: 2327113
  • J Nutr Health.
  • 2013 Aug;46(4):315-323.
This study was conducted in order to compare the biological activities of leaf and root water extracts of Smilax china L. (SC) by measuring the total polyphenol and flavonoid contents,...
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