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Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis

Sun C, Zhu T, Zhu Y, Li B, Zhang J, Liu Y, Juan C, Yang S, Zhao Z, Wan R, Lin S, Yin B

Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives:...
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Glasgow prognostic score and combined positive score for locally advanced rectal cancer

Feng Y, Luo J, Liu P, Liu L, Zhu Y, Cheng G, Zheng L

Purpose: This study was performed to investigate the association of Glasgow prognostic score (GPS), combined positive score (CPS), and clinicopathological characteristics of locally advanced rectal cancer. Methods: Between February 2012 and...
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DEMO: Deep MR Parametric Mapping with Unsupervised Multi-Tasking Framework

Cheng J, Liu Y, Zhu Y, Liang D

Compressed sensing (CS) has been investigated in magnetic resonance (MR) parametric mapping to reduce scan time. However, the relatively long reconstruction time restricts its widespread applications in the clinic. Recently,...
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Hair Growth Promoting Effects of 650 nm Red Light Stimulation on Human Hair Follicles and Study of Its Mechanisms via RNA Sequencing Transcriptome Analysis

Yang K, Tang Y, Ma Y, Liu Q, Huang Y, Zhang Y, Shi X, Zhang L, Zhang Y, Wang J, Zhu Y, Liu W, Tan Y, Lin J, Wu W

Background: Androgenetic alopecia (AGA) leads to thinning of scalp hair and affects 60%~70% of the adult population worldwide. Developing more effective treatments and studying its mechanism are of great significance....
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Clinical and Immunological Factors Associated with Postpartum Hepatic Flares in Immune-Tolerant Pregnant Women with Hepatitis B Virus Infection Treated with Telbivudine

Lu J, Wang X, Zhu Y, Ma L, Zheng S, Hu Z, Chen X

Background/Aims: To investigate postpartum hepatic flares and associated factors in highly viremic pregnant patients in the immune tolerance phase who adopted telbivudine (LdT) treatment in the last trimester to reduce...
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Gastroprotective effect of cirsilineol against hydrochloric acid/ ethanol-induced gastric ulcer in rats

Gong G,  Zhao R, Zhu Y, Yu J, Wei B, Xu Y, Cui Z, Liang G

This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsilineol was administered at the doses of 20 and 40 mg/kg in HCl/ethanol-induced...
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Molecular Correlates and Nuclear Features of Encapsulated Follicular-Patterned Thyroid Neoplasms

Jung CK, Bychkov A, Song DE, Kim JH, Zhu Y, Liu Z, Keelawat S, Lai CR, Hirokawa M, Kameyama K, Kakudo K

Background: Assessing nuclear features is diagnostically challenging in the aspect of thyroid pathology. The aim of this study was to determine whether pathologists could distinguish BRAF-like and RAS-like nuclear features...
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A Novel Mutation p.L461P in KRT5 Causing Localized Epidermolysis Bullosa Simplex

Jiang X, Zhu Y, Sun H, Gu F

Background: Epidermolysis bullosa (EB) is a rare genetic disease with widely different clinical manifestations, but the relationship between genotype and phenotype is not fully understood. In the present study, we...
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Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells

Zhou P, Wei B, Guan J, Chen Y, Zhu Y, Ye Y, Meng Y, Guan J, Mao Y

BACKGROUND: Degeneration of the annulus fibrosus (AF), an important structure of the intervertebral disc, is one of the main causes of degenerative disc disease. Fabrication of scaffolds replicating the stratified...
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Force changes associated with differential activation of en-masse retraction and/or intrusion with clear aligners

Zhu Y, Hu W, Li S

Objective: To investigate the three-dimensional forces created by clear aligners on mandibular teeth during differential activation with en-masse retraction and/or intrusion in vitro. Methods: Six sets of clear aligners were...
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Texture Analysis of Three-Dimensional MRI Images May Differentiate Borderline and Malignant Epithelial Ovarian Tumors

Ye R, Weng S, Li Y, Yan C, Chen J, Zhu Y, Wen L

Objective: To explore the value of magnetic resonance imaging (MRI)-based whole tumor texture analysis in differentiating borderline epithelial ovarian tumors (BEOTs) from FIGO stage I/II malignant epithelial ovarian tumors (MEOTs). Materials...
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Evaluation and Comparison of Predictive Value of Tumor Regression Grades according to Mandard and Becker in Locally Advanced Gastric Adenocarcinoma

Tong Y, Zhu Y, Zhao Y, Shan Z, Liu D, Zhang J

Purpose Tumor regression grade (TRG) has been widely used in gastrointestinal carcinoma to assess pathological responses to neoadjuvant chemotherapy (NCT). There are various standards without a consensus, and it is still...
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Cascaded Residual Dense Networks for Dynamic MR Imaging with Edge-Enhanced Loss Constraint

Ke Z, Zhu Y, Liang D

Dynamic magnetic resonance (MR) imaging has generated great research interest, because it can provide both spatial and temporal information for clinical diagnosis. However, slow imaging speed or long scanning time is...
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A Comparative Study of Unsupervised Deep Learning Methods for MRI Reconstruction

He Z, Quan C, Wang S, Zhu Y, Zhang M, Zhu Y, Liu Q

Recently, unsupervised deep learning methods have shown great potential in image processing. Compared with a large-amount demand for paired training data of supervised methods with a specific task, unsupervised methods...
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Motives for Empathy among Clinical Nurses in China: A Qualitative Study

Zhu Y, He MM, Zhu JM, Huang L, Li BK

Purpose: This study aimed to explore the motives of clinical nurses for experiencing empathy with patients and their families based on a self-determination theory framework. Methods: Semi-structured face-to-face interviews with...
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Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus

Li Y, Zhou Y, Zhao M, Zou J, Zhu Y, Yuan X, Liu Q, Cai H, Chu CQ, Liu Y

Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that...
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Successful Treatment of Psychiatric Symptoms after Traumatic Brain Injury Using Deep Brain Stimulation to the Anterior Limb of Internal Capsule-Nucleus Accumbens

Zhou B, Kuang W, Huang H, Zhu Y, Chen X, Li L, Yang P

Psychiatric symptoms are common after traumatic brain injury (TBI), and some patients have poor drug therapeutic efficacy. We report a successfully treated case of psychiatric symptoms after TBI using deep...
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The Role and Specific Mechanism of OCT4 in Cancer Stem Cells: A Review

Zhang Q, Han Z, Zhu Y, Chen J, Li W

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance. Finding...
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Four active monomers from Moutan Cortex exert inhibitoryeffects against oxidative stress by activating Nrf2/Keap1signaling pathway

Zhang B, Yu D, Luo N, Yang C, Zhu Y

Paeonol, quercetin, -sitosterol, and gallic acid extracted from MoutanCortex had been reported to possess anti-oxidative, anti-inflammatory, and antitumoractivities. This work aimed to illustrate the potential anti-oxidative mechanismof monomers in human...
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Risk Factors for Recurrent Colorectal Polyps

Hao Y, Wang Y, Qi M, He X, Zhu Y, Hong J

The recurrence of colorectal polyps is caused by various factors and leads to the carcinogenesis of colorectal cancer, which ranks third in incidence and fourth in mortality among cancers worldwide....
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