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Human Umbilical Cord Mesenchymal Stem Cells Improve the Necrosis and Osteocyte Apoptosis in Glucocorticoid-Induced Osteonecrosis of the Femoral Head Model through Reducing the Macrophage Polarization

Tian G, Liu C, Gong Q, Yu Z, Wang H, Zhang D, Cong H

Background and Objectives: Apoptosis is an outstanding determinant of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). Human umbilical cord mesenchymal stem cells (hUC-MSCs) have been demonstrated to be associated...
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Addendum to: Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity (J Obes Metab Syndr 2021;30:44-54)

Lee JH, Zhang D, Kwak SE, Shin HE, Song W

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Transcriptome and proteome analysis of pregnancy and postpartum anoestrus ovaries in yak

Chen Z, Wang J, Ma J, Li S, Huo S, Yang Y, Zhaxi Y, Zhao Y, Zhang D

Background: Domestic yaks are the most important livestock species on the Qinghai-Tibetan Plateau. Adult female yaks normally breed in the warm season (July to September) and enter anestrous in the...
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Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p

Pan J, Liu Z, Yang Z, Liang E, Fang C, Zhang D, Zhou X, Niu Y, Xin Z, Chen Y, Cai Q

Purpose: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these...
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Inter-hemispheric Functional Connections Are More Vulnerable to Attack Than Structural Connection in Patients With Irritable Bowel Syndrome

Liu G, Li S, Chen N, Zhao Z, Guo M, Liu H, Feng J, Zhang D, Yao Z, Hu B

  • KMID: 2517537
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):426-435.
  • doi: 10.5056/jnm20134
Background/Aims Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disease characterized by recurrent abdominal pain and bowel dysfunction. However, the majority of previous neuroimaging studies focus on brain structure and...
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Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity

Lee JH, Zhang D, Kwak SE, Shin HE, Song W

Background: Exercise and high fat, high sucrose restriction diets are well known treatments for obesity. The aim of this study was to measure the effects of those lifestyle interventions on...
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Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population

Zou Y, Wang D, Cheng X, Ma C, Lin S, Hu Y, Yu S, Xia L, Li H, Yin Y, Liu H, Zhang D, Zhang K, Lian X, Xu T, Qiu L

Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thyroid-associated hormones and evaluated the prevalence of thyroid diseases in China. Methods:...
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Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney

Zhang J, Li K, Kong F, Sun C, Zhang D, Yu X, Wang X, Li X, Liu T, Shao G, Guan Y, Zhao S

BACKGROUND: Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once...
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Exercise, the Gut Microbiome, and Frailty

Shin HE, Kwak SE, Lee JH, Zhang D, Bae JH, Song W

The gut microbiome is deeply associated with both skeletal muscle and brain function. In particular, gut microbiome dysbiosis may accelerate age-related diseases by affecting these systems. Although there is increasing...
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Effect of a Single Bout of Exercise on Autophagy Regulation in Skeletal Muscle of High-Fat High-Sucrose Diet-Fed Mice

Zhang D, Lee JH, Kwak SE, Shin HE, Zhang Y, Moon HY, Shin DM, Seong JK, Tang L, Song W

BACKGROUND: Autophagy maintains metabolic homeostasis of muscles, and its impairment may cause muscle dysfunction. Exercise can improve muscle dysfunction induced by long-term high-fat diet. This study aimed to explore the...
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miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer

Yang L, Cai Y, Zhang D, Sun J, Xu C, Zhao W, Jiang W, Pan C

PURPOSE: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7...
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Effects of Single Vitamin D₃ Injection (200,000 Units) on Serum Fibroblast Growth Factor 23 and Sclerostin Levels in Subjects with Vitamin D Deficiency

Zhang D, Seo DH, Choi HS, Park HS, Chung YS, Lim SK

BACKGROUND: Vitamin D deficiency remains common in all age groups and affects skeletal and non-skeletal health. Fibroblast growth factor 23 is a bone-derived hormone that regulates phosphate and 1,25-dihydroxyvitamin D...
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Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model

Zhang YD, Zhu ZS, Zhang D, Zhang Z, Ma B, Zhao SC, Xue F

This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI). An analytical emphasis...
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Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT² Profiler PCR Array and immunochemistry assays

Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D

The Wnt signaling pathway and its key component β-catenin have critical roles in the development of diseases such as tumors in mammals. However, little has been reported about involvement of...
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Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model

Park BM, Kim EJ, Nam HJ, Zhang D, Bae CH, Kang M, Kim H, Lee W, Bogen B, Lim SK

PURPOSE: Dickkopf 1 (DKK1) has been extensively investigated in mouse models of multiple myeloma, which results in osteolytic bone lesions. Elevated DKK1 levels in bone marrow plasma and serum inhibit...
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Risk Factors for the Rupture of Bifurcation Intracranial Aneurysms Using CT Angiography

Wang GX, Zhang D, Wang ZP, Yang LQ, Zhang L, Wen L

PURPOSE: To investigate the clinical and morphological characteristics in relation to risk of bifurcation intracranial aneurysm rupture. MATERIALS AND METHODS: Data from 202 consecutive patients with 219 bifurcation aneurysms (129 ruptured...
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The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study

Huang J, Zhang D, Xie F, Lin D

Increasing evidence suggests that cancer stem cells (CSCs) are responsible for tumor initiation and maintenance. Additionally, it is becoming apparent that cyclooxygenase (COX) signaling is associated with canine mammary tumor...
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Weight Gain in Pregnancy, Maternal Age and Gestational Age in Relation to Fetal Macrosomia

Li Y, Liu QF, Zhang D, Shen Y, Ye K, Lai HL, Wang HQ, Hu CL, Zhao QH, Li L

To investigate the possible risk factors related to macrosomia. Pregnant women and their newborns (n = 1041) were recruited from a cohort study in Maternal and Child Care Center of...
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Selective Estrogen Receptor Modulation by Larrea nitida on MCF-7 Cell Proliferation and Immature Rat Uterus

Ahn HN, Jeong SY, Bae GU, Chang M, Zhang D, Liu X, Pei Y, Chin YW, Lee J, Oh SR, Song YS

  • KMID: 2170630
  • Biomol Ther.
  • 2014 Jul;22(4):347-354.
Larrea nitida is a plant that belongs to the Zygophyllaceae family and is widely used in South America to treat inflammatory diseases, tumors and menstrual pain. However, its pharmacological activity...
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Detection of Acute Toxoplasmosis in Pigs Using Loop-Mediated Isothermal Amplification and Quantitative PCR

Wang Y, Wang G, Zhang D, Yin H, Wang M

  • KMID: 1792151
  • Korean J Parasitol.
  • 2013 Oct;51(5):573-577.
A loop-mediated isothermal amplification (LAMP) assay allows rapid diagnosis of Toxoplasma gondii infection. In the present study, the LAMP assay was evaluated using blood from both naturally and experimentally infected...
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