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SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia

Wang Q, Zhang Y, Du Q, Zhao X, Wang W, Zhai Q, Xiang M

Spinal nerve injury causes mechanical allodynia and structural imbalance of neurotransmission, which were typically associated with calcium overload. Storeoperated calcium entry (SOCE) is considered crucial elements-mediating intracellular calcium homeostasis, ion...
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Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/ PKA/CREB signaling pathway in the trigeminal ganglion in rats

Zhai Q, Wang K, Zhang D, Chen J, Dong X, Pan Y

Background: Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this...
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