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The Morphological Changes by the Time of Administration of Zanamivir in Rabbit Nasal Mucosa Infected with Influenza A Virus

Park HJ, Lim JW, Rho YS, Jung YG

  • KMID: 2276570
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Feb;49(2):174-181.
BACKGROUND AND OBJECTIVES: This study aimed to investigate the differences in the morphologic changes of the nasal mucosa with influenza virus infection between zanamivir treated groups and non-treated group. MATERIALS AND...
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Frequently used antiviral agents in the clinical environment

Han S, Yim DS

More than 60 antiviral agents for various infectious diseases such as herpes, hepatitis, influenza, and AIDS are currently prescribed worldwide. Among the viral infections, hepatitis B and influenza are those...
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Influenza

Ryu SY

Influenza causes variable epidemics annually and imposes public health problems and socioeconomic burden. They cause epidemic acute respiratory disease, characterized by fever, cough and systemic symptoms. The annual epidemics of...
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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009)

Hong HL, Kim JH, Yi HJ, Kwon HH

  • KMID: 2406172
  • Infect Chemother.
  • 2010 Apr;42(2):103-106.
In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009,...
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Treatment and prophylaxis of influenza

Lee JS

Influenza is an acute respiratory disease caused by the influenza virus. Each year, it causes a significant disease burden, especially in older adults. Furthermore, influenza pandemics occasionally occur because of...
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Diagnosis and Management of Novel Influenza A (H1N1)

Wie SH, Kim WJ

Since the World Health Organization has officially declared a global influenza pandemic, the number of human cases of pandemic influenza A (H1N1) in 2009 has been increasing in many countries....
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Amantadine and Zanamivir Resistance of Influenza A/H3N2 Viruses Isolated in Korea, 2002/03~2003/04

Kim KA, Lee JY, Kim W, Kim Y, Park YK, Kang C

To investigate the emergence and prevalence of antiviral resistance, we analyzed influenza A/H3N2 viruses isolated in Korea during 2002/03 to 2003/04 season by genetic and phenotypic assay. For the genetic...
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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia

Lee YH, Kim HY, Kim HS, Uh Y, Kim YK, Kim BR, Jung HY, Kim WT, Yi H

  • KMID: 2406173
  • Infect Chemother.
  • 2010 Apr;42(2):107-111.
Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of...
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Zanamivir Oral Delivery: Enhanced Plasma and Lung Bioavailability in Rats

Shanmugam , Im HT, Sohn YT, Kim KS, Kim YI, Yong CS, Kim JO, Choi HG, Woo JS

  • KMID: 1502519
  • Biomol Ther.
  • 2013 Mar;21(2):161-169.
The objective of this study was to enhance the oral bioavailability (BA) of zanamivir (ZMR) by increasing its intestinal permeability using permeation enhancers (PE). Four different classes of PEs (Labrasol(R),...
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First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea

Hong SD, Park SH, Kang SJ, Kwon YS, Kee SJ, Park KH, Jung SI, Jang HC

It has been suggested that oseltamivir-resistant influenza viruses harboring the H274/275Y mutation are less virulent than are those that are oseltamivir-sensitive, and fatality attributed to infection with an oseltamivir-resistant virus...
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Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons

Kim SG, Hwang YH, Shin YH, Kim SW, Jung WS, Kim SM, Oh JM, Lee NY, Kim MJ, Cho KS, Park YG, Min SK, Lee CK, Kim JS, Kang C, Lee JY, Huh MK, Kim CH

PURPOSE: There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant...
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Epidemiological and Clinical Characteristics of Pandemic Influenza (H1N1 2009)

Noh JY, Yim SY, Heo JY, Choi WS, Song JY, Cheong HJ, Kim WJ

  • KMID: 2406165
  • Infect Chemother.
  • 2010 Apr;42(2):69-75.
BACKGROUND: Since early outbreaks in North America in April 2009, the new influenza virus spread rapidly all over the world, and WHO declared a pandemic in June 2009. The objective...
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