- Molecular Cloning of Mouse Interleukin-2 Receptor bata-Chain Gene Promoter
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Ko CK, Ye SK, Min BH, Lee KH
- KMID: 1928278
- Korean J Immunol.
- 1998 Sep;20(3):285-288.
No abstract available. -
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- Chronic Non-Social Stress Affects Depressive Behaviors But Not Anxiety in Mice
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Yoon SH, Kim BH, Ye SK, Kim MH
- KMID: 2285519
- Korean J Physiol Pharmacol.
- 2014 Jun;18(3):263-268.
- doi: 10.4196/kjpp.2014.18.3.263
The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress... -
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- Interleukin-7 Receptor is Indispensable for Proliferation and Survival in Thymic gamma sigma T Cell Development
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Kim DH, Yoon BH, Jung JE, Kim HS, Ko SH, Choi EY, Lee KH, Kim K, Ye SK, Chung MH
- KMID: 2150586
- Immune Netw.
- 2005 Mar;5(1):23-29.
- doi: 10.4110/in.2005.5.1.23
BACKGROUND: Interleukin-7 receptor (IL-7R) alpha-deficient mice have small numbers of B cells and alpha beta T cells in periphery, they totally lack gamma sigma T cells. In addition, the V-J... -
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- Effect of Denosumab on the Change of Osteoclast Precursors Compared to Zoledronate Treatment in Postmenopausal Women with Osteoporosis
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Kong SH, Kim JH, Kim SW, Jeong AJ, Lee SH, Ye SK, Shin CS
- KMID: 2530515
- J Bone Metab.
- 2022 May;29(2):93-101.
- doi: 10.11005/jbm.2022.29.2.93
Background: A rapid increase in bone turnover and bone loss has been observed in response to the discontinuation of denosumab. It led to an acute increase in the fracture risk,... -
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- Comparison of anti-oxidant activities of seventy herbs that have been used in Korean traditional medicine
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Ko SH, Choi SW, Ye SK, Yoo S, Kim HS, Chung MH
- KMID: 2313363
- Nutr Res Pract.
- 2008 Sep;2(3):143-151.
Many herbs have been used as therapeutics in Korean traditional medicine. In view of their clinical indications, anti-oxidant activity may contribute to their pharmacological effects. However, anti-oxidant information on these... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- STAT3 inhibits the degradation of HIF-1alpha by pVHL-mediated ubiquitination
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Jung JE, Kim HS, Lee CS, Shin YJ, Kim YN, Kang GH, Kim TY, Juhnn YS, Kim SJ, Park JW, Ye SK, Chung MH
- KMID: 1104801
- Exp Mol Med.
- 2008 Oct;40(5):479-485.
- doi: 10.3858/emm.2008.40.5.479
Hypoxia-inducible factor 1alpha (HIF-1alpha) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1alpha is mediated by interaction with von Hippel-Lindau tumor suppressor protein (pVHL). In our... -
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- T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
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Kwon SH, Seo EB, Lee SH, Cho CH, Kim SJ, Kim SJ, Kim HR, Ye SK
- KMID: 2419775
- Immune Netw.
- 2018 Aug;18(4):e30.
- doi: 10.4110/in.2018.18.e30
Signal transducer and activator of transcription 3 (STAT3) has a crucial role in various autoimmune disorders including, inflammatory bowel disease (IBD). Our previous study demonstrated that STAT3 activation by IL-6... -
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- LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
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Kim JE, Kim HS, Shin YJ, Lee CS, Won C, Lee SA, Lee JW, Kim Y, Kang JS, Ye SK, Chung MH
- KMID: 1104805
- Exp Mol Med.
- 2008 Oct;40(5):514-522.
- doi: 10.3858/emm.2008.40.5.514
Tumor migration/invasion is the main cause of tumor progression and STAT3 is needed to enhance tumor migration/invasion by up-regulating MMP-9. Thus, agents that inhibit STAT3 activation may be used as... -
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- Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
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Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH
- KMID: 1110126
- Exp Mol Med.
- 2006 Aug;38(4):417-427.
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and the underlying mechanisms in... -
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- Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
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Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK
- KMID: 2458858
- J Breast Cancer.
- 2019 Sep;22(3):362-374.
- doi: 10.4048/jbc.2019.22.e34
PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate... -
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- Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling
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Kim BH, Min YS, Choi JS, Baeg GH, Kim Y, Shin JW, Kim TY, Ye SK
- KMID: 1009971
- Exp Mol Med.
- 2011 May;43(5):313-321.
- doi: 10.3858/emm.2011.43.5.035
Persistently activated JAK/STAT3 signaling pathway plays a pivotal role in various human cancers including major carcinomas and hematologic tumors, and is implicated in cancer cell survival and proliferation. Therefore, inhibition... -
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- Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
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Joung YH, Lim EJ, Lee MY, Park JH, Ye SK, Park EU, Kim SY, Zhang Z, Lee KJ, Park DK, Park T, Moon WK, Yang YM
- KMID: 1093470
- Exp Mol Med.
- 2005 Aug;37(4):353-364.
Hypoxia, a common consequence of solid tumor growth in breast cancer or other cancers, serves to propagate a cascade of molecular pathways which include angiogenesis, glycolysis, and various cellcycle control... -
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