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Immune Monitoring of Cancer Vaccines

Wang E, Panelli MC, Monsurro V, Ping J, Zavaglia K, Marincola

The recent progress in tumor immunology exemplifies the successful application of modern biotechnology for the understanding of the complex natural or therapy-induced phenomenon of immune-mediated rejection of cancer. Tumor antigens...
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Quality assessment of cellular therapies: the emerging role of molecular assays

Stroncek D, Jin P, Ren J, Feng J, Castiello , Civini S, Wang E, Marincola , Sabatino M

Cellular therapies are becoming increasingly important in treating cancer, hematologic malignancies, autoimmune disorders, and damaged tissue. These therapies are becoming more effective and are being used more frequently, but they...
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Cloning and Expression of Recombinant Tick-Borne Encephalitis Virus-like Particles in Pichia pastoris

Yun SM, Jeong YE, Wang E, Lee YJ, Han MG, Park C, Lee WJ, Choi W

Objectives The purpose of this study was to verify the feasibility of using the glyceraldehyde-3-phosphate dehydrogenase (GAP) promotor based Pichia pastoris expression system to produce tick-borne encephalitis virus (TBEV) virus-like particles...
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Sensitizing endometrial cancer to ionizing radiation by multi-tyrosine kinase inhibition

Wang E, Sorolla A

Objective: Endometrial carcinoma is the most frequent gynecological cancer. About 15% of these cancers are of high risk and radiotherapy still remains the most suitable treatment. In this context, agents...
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Pre-operative fasting times for clear liquids at a tertiary children’s hospital; what can be improved?

Schmidt AR, Fehr J, Man J, D’Souza G, Wang E, Claure R, Mendoza J

Background: The goal of preoperative fasting is to prevent pulmonary aspiration during general anesthesia. Fasting times are often prolonged leading to patient discomfort and risk for adverse events. This retrospective...
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Dual Component Analysis for In Vivo T₂* Decay of Hyperpolarized ¹³C Metabolites

Joe E, Lee J, Lee H, Yang S, Choi YS, Wang E, Song HT, Kim DH

PURPOSE: To investigate the exchange and redistribution of hyperpolarized ¹³C metabolites between different pools by temporally analyzing the relative fraction of dual T₂* components of hyperpolarized ¹³C metabolites. MATERIALS AND METHODS:...
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Mechanism of Immune Response During Immunotherapy

Panelli MC, Nagorsen D, Wang E, Monsurro V, Jin P, Katia Z, Smith K, Ngalame Y, Marincola

Tumor immunology embraces an extensive array of biological phenomena that include interactions between neoplastic cells and the innate and adaptive immune response. Among immune cells, T cells have taken the...
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Determination of Optimal Scan Time for the Measurement of Downstream Metabolites in Hyperpolarized 13C MRSI

Lee H, Lee J, Joe E, Yang S, Choi YS, Wang E, Song HT, Kim DH

PURPOSE: For a single time-point hyperpolarized 13C magnetic resonance spectroscopy imaging (MRSI) of animal models, scan-time window after injecting substrates is critical in terms of signal-to-noise ratio (SNR) of downstream...
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Silencing of Fanconi Anemia Complementation Group F Exhibits Potent Chemosensitization of Mitomycin C Activity in Breast Cancer Cells

Yu J, Zhao L, Li Y, Li N, He M, Bai X, Yu Z, Zheng Z, Mi X, Wang E, Wei M

PURPOSE: Fanconi anemia complementation group F (FANCF) is a key factor to maintaining the function of Fanconi anaemia/BRCA (FA/BRCA) pathway, a DNA-damage response pathway. However, the functional role of FANCF...
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Human Acellular Dermis versus Submuscular Tissue Expander Breast Reconstruction: A Multivariate Analysis of Short-Term Complications

Davila AA, Seth AK, Wang E, Hanwright , Bilimoria , Fine N, Kim JY

BACKGROUND: Acellular dermal matrix (ADM) allografts and their putative benefits have been increasingly described in prosthesis based breast reconstruction. There have been a myriad of analyses outlining ADM complication profiles,...
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Detection and Isolation of SARS-CoV-2 in Serum, Urine, and Stool Specimens of COVID-19 Patients from the Republic of Korea

Kim JM, Kim HM, Lee EJ, Jo HJ, Yoon Y, Lee NJ, Son J, Lee YJ, Kim MS, Lee YP, Chae SJ, Park KR, Cho SR, Park S, Kim SJ, Wang E, Woo S, Lim A, Park SJ, Jang J, Chung YS, Chin BS, Lee JS, Lim D, Han MG, Yoo CK

Objectives Coronavirus Disease-19 (COVID-19) is a respiratory infection characterized by the main symptoms of pneumonia and fever. It is caused by the novel coronavirus severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), which...
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