- Hepatitis C virus: virology and life cycle
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Kim CW, Chang KM
- KMID: 1493570
- Clin Mol Hepatol.
- 2013 Mar;19(1):17-25.
- doi: 10.3350/cmh.2013.19.1.17
Hepatitis C virus (HCV) is a positive sense, single-stranded RNA virus in the Flaviviridae family. It causes acute hepatitis with a high propensity for chronic infection. Chronic HCV infection can... -
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- Emerging Therapies for Hepatitis C
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Kim DY, Ahn SH, Han KH
- KMID: 2070056
- Gut Liver.
- 2014 Sep;8(5):471-479.
- doi: 10.5009/gnl14083
The combination of pegylated interferon (PEG-IFN) and ribavirin (RBV), the current therapy for hepatitis C virus (HCV) infection, has saved the lives of many HCV-infected patients. Direct-acting antivirals (DAAs) target... -
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- Expression of hepatitis C virus nonstructural 4B in transgenic mice
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Wang AG, Moon HB, Kim JM, Hwang SB, Yu DY, Lee DS
- KMID: 1094149
- Exp Mol Med.
- 2006 Jun;38(3):241-246.
Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated... -
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- New Therapeutic Agent for Chronic Hepatitis C: Direct Acting Agent
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Chae HB
- KMID: 2373305
- Korean J Gastroenterol.
- 2015 Jul;66(1):5-9.
- doi: 10.4166/kjg.2015.66.1.5
Peg-interferon and ribavirin has been the standard therapy of chronic hepatitis C for the past 15 years in Korea. However, the treatment paradigm is changing. Direct acting agents (DAAs) are... -
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- Immunogenicity of baculovirus expressed recombinant proteins of Japanese encephalitis virus in mice
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Yang DK, Kweon CH, Kim BH, Lim SI, Kwon JH, Kim SH, Song JY, Han HR
- KMID: 1114853
- J Vet Sci.
- 2005 Jun;6(2):125-133.
Genes encoding for the premembrane and envelope (prME), envelope (E) and nonstructural protein (NS1) of Japanese encephalitis virus (JEV) were cloned. Each protein was expressed in baculovirus expression system. Of... -
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- The prediction of interferon-alpha therapeutic effect by sequence variation of the HCV hypervariable region 1
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Yeh BI, Kim HW, Kim HS, Lee JY, Lee KH, Lee KM, Kim JS, Han KH
- KMID: 711674
- Yonsei Med J.
- 1999 Oct;40(5):430-438.
- doi: 10.3349/ymj.1999.40.5.430
Interferon-alpha (IFN-alpha) has been used to treat hepatitis C virus (HCV)-induced hepatitis, but it has been effective in only about half of the treated patients, with recurrence appearing in the... -
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- Development of synthetic peptide ELISA based on nonstructural protein 2C of foot and mouth disease virus
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Oem JK, Kye SJ, Lee KN, Park JH, Kim YJ, Song HJ, Yeh M
- KMID: 1090767
- J Vet Sci.
- 2005 Dec;6(4):317-325.
It was reported that the sera of convalescent animals contain antibodies to foot and mouth disease (FMD) virus (FMDV) 2C, highly conserved nonstructural protein (NSP), whereas the sera of vaccinated... -
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- Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene
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Saurabh S, Sircar S, Kattoor JJ, Ghosh S, Kobayashi , Banyai K, VinodhKumar OR, De UK, Sahoo NR, Dhama K, Malik YS
- KMID: 2402693
- J Vet Sci.
- 2018 Jan;19(1):35-43.
- doi: 10.4142/jvs.2018.19.1.35
Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with... -
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- Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells
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Choi HB, Kim YG, Oh JW
- KMID: 1119328
- Exp Mol Med.
- 2003 Dec;35(6):475-485.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B protein, is the key viral enzyme responsible for replication of the HCV viral RNA genome. Although several full-length and truncated forms... -
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- Monitoring antibody titers to recombinant Core-NS3 fusion polypeptide is useful for evaluating hepatitis C virus infection and responses to interferon-alpha therapy
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Park YM, Byun BH, Choi JY, Bae SH, Kim BS, So HS, Ryu WS
- KMID: 648075
- J Korean Med Sci.
- 1999 Apr;14(2):165-170.
- doi: 10.3346/jkms.1999.14.2.165
To evaluate the clinical feasibility of the antibody titer against a chimeric polypeptide (named Core 518), in which a domain of Core and NS3 of hepatitis C virus (HCV) was... -
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- The relationship between virological characteristics of hepatitis C virus (HCV) and reactivity to the regional specific proteins of HCV
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Yoon SK, Park YM, Byun BH, Bae SH, Yang JM, Ahn BM, Lee YS, Lee CD, Sun HS, Kim BS
- KMID: 759502
- Korean J Intern Med.
- 2000 Jul;15(2):109-116.
BACKGROUND: Although the polyproteins of hepatitis C virus(HCV) are processed and formed in nearly equimolar amounts, individual functional proteins have a discrepancy... -
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- Viral loads and E2/NS1 region sequences of hepatitis C virus in hepatocellular carcinoma and surrounding liver
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Park CK, Park TR, Kim YB, Kim HY, Yoo JY, Kim CH, Choo SH, Cho JM
- KMID: 1038874
- Korean J Intern Med.
- 1997 Jan;12(1):28-33.
OBJECTIVES: Numerous epidemiologic data have documented that chronic infection by hepatitis C virus (HCV) is a major risk factor for the development of hepatocellular carcinoma (HCC). But the molecular mechanism... -
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- Efficacy and safety of daclatasvir plus asunaprevir for Korean patients with HCV genotype Ib infection: a retrospective multi-institutional study
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Cho BW, Kim SB, Song IH, Lee SH, Kim HS, Lee TH, Kang YW, Kim SH, Lee BS, Chae HB
- KMID: 2412114
- Clin Mol Hepatol.
- 2017 Mar;23(1):51-56.
- doi: 10.3350/cmh.2016.0053
BACKGROUND/AIMS: The combination of daclatasvir (DCV) and asunaprevir (ASV) has demonstrated a high sustained virologic response at 12 weeks (SVR12) and a low rate of adverse events in previous clinical... -
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- Molecular characterization of a 13-amino acid deletion in VP1 (1D) protein and novel amino acid substitutions in 3D polymerase protein of foot and mouth disease virus subtype A/Iran87
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Esmaelizad M, Jelokhani-Niaraki S, Hashemnejad K, Kamalzadeh M, Lotfi M
- KMID: 1365020
- J Vet Sci.
- 2011 Dec;12(4):363-371.
- doi: 10.4142/jvs.2011.12.4.363
The nucleotide sequence of the VP1 (1D) and partial 3D polymerase (3Dpol) coding regions of the foot and mouth disease virus (FMDV) vaccine strain A/Iran87, a highly passaged isolate (~150... -
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- New treatments for chronic hepatitis C
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Jang JY, Chung RT
- KMID: 1717320
- Korean J Hepatol.
- 2010 Sep;16(3):263-277.
- doi: 10.3350/kjhep.2010.16.3.263
Treatments for chronic hepatitis C has evolved significantly in the past 15 years. The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in... -
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- Sequence and phylogenetic analysis of the non-structural 3A and 3B protein-coding regions of foot-and-mouth disease virus subtype A Iran 05
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Jelokhani-Niaraki S, Esmaelizad M, Daliri M, Vaez-Torshizi R, Kamalzadeh M, Lotfi M
- KMID: 1093499
- J Vet Sci.
- 2010 Sep;11(3):243-247.
- doi: 10.4142/jvs.2010.11.3.243
The A Iran 05 foot-and-mouth disease virus (FMDV) subtype was detected in Iran during 2005 and has proven to be highly virulent. This study was undertaken to focus on molecular... -
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