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Effective Antitumor Activity of a Recombinant Vaccinia Virus Expressing Murine Interleukin 4

Yoon K, Kim S, Jin NY

  • KMID: 1940947
  • J Korean Soc Virol.
  • 1998 Mar;28(1):71-78.
Vaccinia virus is the prototype orthopoxvirus that has been used as a vaccine strain for small pox. This virus has been used to express a variety of cellular and viral...
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A Quantitative Comparison of Vaccinia Virus Shedding from Conventional Dressing Sites and Vaccination Lesions after Smallpox Vaccination

Kim SH, Yeo SG, Cho JH, Bang JW, Kim HB, Kim NJ, Jee Y, Cho H, Oh MD, Choe KW

  • KMID: 1523519
  • Infect Chemother.
  • 2007 Apr;39(2):78-84.
BACKGROUND: We compared vaccinia virus shedding from the vaccine inoculation site (vaccination lesion) and two sites of a dressing covering the vaccination site; the outer surface of the semipermeable dressing...
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CD8+ T Cell-mediated Immunity Induced by Heterologous Prime-boost Vaccination Based on DNA Vaccine and Recombinant Vaccinia Virus Expressing Epitope

Park SO, Yoon HA, Aleyas AG, Lee JH, Chae JS, Eo SK

BACKGROUND: DNA vaccination represents an anticipated approach for the control of numerous infectious diseases. Used alone, however, DNA vaccine is weak immunogen inferior to viral vectors. In recent, heterologous prime-boost...
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Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens

Zanetti FA, Zajac MP, Taboga OA, Calamante

A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated...
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In vivo CTL Activity Induced by Prime-boost Vaccination using Recombinant Vaccinia Virus and DNA Vaccine Expressing Epitope Specific for CD8+ T Cells

Han YW, Park SO, Kim AR, Aleyas AG, George JA, Yoon HA, Eo SK

DNA vaccine approaches have been applied to generate the protective immunity against various pathogens. However, the strength of immune responses induced by DNA vaccine is weak compared with conventional vaccines....
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Distinct Humoral and Cellular Immunity Induced by Alternating Prime-boost Vaccination Using Plasmid DNA and Live Viral Vector Vaccines Expressing the E Protein of Dengue Virus Type 2

George JA, Eo SK

BACKGROUND: Dengue virus, which belongs to the Flavivirus genus of the Flaviviridae family, causes fatal dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) with infection risk of 2.5 billion...
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Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines

Lee HJ, Rho J, Gui SR, Kim MK, Lee YK, Lee YS, Kim JE, Cho E, Cho M, Hwang TH

BACKGROUND/AIMS: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma...
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Expression and localization of human papillomavirus type 16 E6 and E7 open reading frame proteins in human epidermal keratinocyte

Kim KH, Yoon DJ, Moon YA, Kim YS

Over 60 different types of human papillomavirus (HPV) have been identified, and they are classified into high and low risk groups based on the risk for malignant progression of HPV...
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Requirement of CD4 Help for Induction of CD8 T Cell Response Specific for Virally Derived H60

Ryu SJ, Kang B, Kim SH, Kim TW, Chang J, Choi EY

CD40-CD40L-mediated help from CD4 T cells is essential to induce primary CD8 T cell responses specific to the non-inflammatory cell-based antigen H60. In this study, using H60 as a model...
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Anti-tumoral Effect of Recombinant Vaccinia Virus through US Guided Injection in a Rabbit Model of Hepatic VX2 Carcinoma

Oh JY, Park BH, Kang MJ, Cho JH, Choi JC, Choi S, Nam KJ, Hwang TH, Jeong JS

PURPOSE: The purpose of this study was to evaluate the anti-tumoral effect of recombinant vaccinia virus (rVV) (Thymidine kinase (-)/GM-CSF (+)) that was administered as a US guided intratumoral...
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Vanilloid Receptor 1 Agonists, Capsaicin and Resiniferatoxin, Enhance MHC Class I-restricted Viral Antigen Presentation in Virus-infected Dendritic Cells

Lee YH, Im SA, Kim JW, Lee CK

DCs, like the sensory neurons, express vanilloid receptor 1 (VR1). Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class...
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Relationship between Poor Immunogenicity of HLA-A2-Restricted Peptide Epitopes and Paucity of Naive CD8+ T-Cell Precursors in HLA-A2-Transgenic Mice

Choi YS, Lee DH, Shin EC

We examined the immunogenicity of H-2 class I-restricted and HLA-A2-restricted epitopes through peptide immunization of HLA-A2-transgenic mice that also express mouse H-2 class I molecules. All four of the tested...
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Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity

Kim AR, Park J, Kim JH, Kwak JE, Cho Y, Lee H, Jeong M, Park SH, Shin EC

Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression....
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Protective Effects on A2Kb Transgenic Mice That Were Immunized with Hepatitis B Virus X Antigen Peptides by the Activation of CD8? T Cells; XEP-3 Specific CTL Responses in the in vitro Culture

Hwang YK, Kim HI, Kim NK, Park JM, Cheong HS

BACKGROUND: Viral antigens presented on the cell surface in association with MHC class I molecules are recognized by CD8+ T cells. MHC restricted peptides are important in eliciting cellular immune...
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