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TT Virus Detection Using Different PCR Primer Sets in Healthy and Infected Individuals with Hepatitis B or C Viruses

Kim HS, Kim JS, Song W, Kang HJ, Lee KM

  • KMID: 2224732
  • Korean J Clin Microbiol.
  • 2007 Apr;10(1):14-18.
BACKGROUND: TT virus (TTV) infection is highly prevalent in the general population and in the patients infected with hepatitis B virus (HBV) or hepatitis C vius (HCV). The aim of...
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Structure and Expression Analyses of SVA Elements in Relation to Functional Genes

Kwon YJ, Choi Y, Eo J, Noh YN, Gim JA, Jung YD, Lee JR, Kim HS

SINE-VNTR-Alu (SVA) elements are present in hominoid primates and are divided into 6 subfamilies (SVA-A to SVA-F) and active in the human population. Using a bioinformatic tool, 22 SVA element-associated...
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High Correlation between Alu Elements and the Conversion of 3' UTR of mRNAs Processed Pseudogenes

An HJ, Na D, Lee D, Lee KH, Bhak J

  • KMID: 2166170
  • Genomics Inform.
  • 2004 Jun;2(2):86-91.
Even though it represents 6 13% of human genomic DNA, Alu sequences are rarely found in coding regions. When in exon region, over 80 % of them are found in...
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Mechanisms of Myotonic Dystrophies 1 and 2

Lubov T

  • KMID: 2285303
  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):1-8.
Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2)...
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Complete Nucleotide Sequence of Genomic RNA of a Large-Plaque Forming Porcine Reproductive and Respiratory Syndrome Virus PL97-1/LP1

Lee YM

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important animal pathogens in swine industry worldwide. In this study, we isolated the large-plaque forming variant virus designated...
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Genomic Analysis of miR-21-3p and Expression Pattern with Target Gene in Olive Flounder

Jo A, Lee HE, Kim HS

MicroRNAs (miRNAs) act as regulators of gene expression by binding to the 3’ untranslated region (UTR) of target genes. They perform important biological functions in the various species. Among many...
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Development of an efficient endothelial cell specific vector using promoter and 5' untranslated sequences from the human preproendothelin-1 gene

Cho JY, Lim WC, Jang S, Lee YJ

  • KMID: 1109315
  • Exp Mol Med.
  • 2003 Aug;35(4):269-274.
We report here, that a vector constructed based on ppET-1 gene promoter and 5' untranslated region induced a high level of gene expression in endothelial cells and the specificity is...
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miR-526b targets 3' UTR of MMP1 mRNA

Kim KH, Jung JY, Son ED, Shin DW, Noh M, Lee TR

Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1...
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The Role of MicroRNAs in Regulatory T Cells and in the Immune Response

Ha TY

The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent years and has revolutionized current cell biology and medical science. miRNAs are small (19~25nt) noncoding RNA...
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Transcriptional Activity of Plasmodium Subtilisin-like Protease 2 (Pf-Sub2) 5'Untranslated Regions and Its Interaction with Hepatocyte Growth Factor

Liao S, Liu Y, Jung SY, Cho PY, Zheng B, Park H

The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors and individual host responses to these determinants. In both humans and mice, liver injury is...
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MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease

Ha TY

The great discovery of microRNAs (miRNAs) has revolutionized current cell biology and medical science. miRNAs are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3'...
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Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA

Kim JK, Kim I, Choi K, Choi JH, Kim E, Lee HY, Park J, Kim Yoon S

During the hair follicle (HF) cycle, HR protein expression is not concordant with the presence of the Hr mRNA transcript, suggesting an elaborate regulation of Hr gene expression. Here we...
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Publicly Available Single Nucleotide Polymorphisms in Genes Possibly Susceptible to Antiepileptic Drug Resistance in Healthy Koreans

Kim MK, Choi KH, Nam TS, Kim JT, Choi SM, Park MS, Kim BC, Cho KH

  • KMID: 2065719
  • J Korean Neurol Assoc.
  • 2010 May;28(2):85-90.
BACKGROUND: The completion of the human genome project means that a high-quality reference sequence of the gene-rich portion of the human genome is now available. However, the strong influence of...
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Association between the Genetic Polymorphisms of the Biogenic Amine Transporters and the Antidepressant Responsiveness in Korean Depressed Patients

Kim DK, Kim EJ, Lim SW, Kim H

  • KMID: 2287338
  • Korean J Psychopharmacol.
  • 2003 Sep;14(3):274-283.
OBJECTIVE: Serotonin transporter (5-HTT) is a key synaptic regulator of serotonergic neurotransmission and a major site of action of most antidepressants. The functional polymorphism of 5-HTT gene is reported to...
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Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines

Shin SO, Lee KH, Kim JH, Baek SH, Park JW, Gabrielson EW, Kwon TK

  • KMID: 755098
  • Exp Mol Med.
  • 2000 Dec;32(4):193-196.
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there...
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Prediction of Mammalian MicroRNA Targets : Comparative Genomics Approach with Longer 3' UTR Databases

Nam S, Kim YK, Kim P, Kim VN, Shin S, Lee S

  • KMID: 1572671
  • Genomics Inform.
  • 2005 Sep;3(3):53-62.
MicroRNAs play an important role in regulating gene expression, but their target identification is a difficult task due to their short length and imperfect complementarity. Burge and coworkers developed a...
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Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells

Choi HB, Kim YG, Oh JW

  • KMID: 1119328
  • Exp Mol Med.
  • 2003 Dec;35(6):475-485.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B protein, is the key viral enzyme responsible for replication of the HCV viral RNA genome. Although several full-length and truncated forms...
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Transient Complete Atrioventricular Block in a Preterm Neonate with Congenital Myotonic Dystrophy: Case Report

Kim HN, Cho YK, Cho JH, Yang EM, Song ES, Choi YY

Congenital myotonic dystrophy (CMD) is an inherited neuromuscular disorder with cardiac rhythm abnormalities that may occur as a child grows. No report has described complete atrioventricular (AV) block detected in...
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Polymorphisms in the STAT-6 Gene and SLE

Rho YH, Kim HJ, Choi SJ, Ji JD, Lee YH, Song GG

  • KMID: 1585322
  • J Korean Rheum Assoc.
  • 2005 Mar;12(1):26-29.
OBJECTIVES: To investigate whether the new polymorphism at position 2964 (G/A) in the 3' untranslated region of the STAT-6 gene is associated with susceptibility to systemic lupus erythematosus (SLE) and...
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A case of congenital myotonic dystrophy: Molecular diagnosis and clinical study

Kim YJ, Kim MY, Lee BY, Kim JW, Park SY, Kim JE, Oh DC, Hong JS, Han HK, Kim MJ, Chun YK, Kim HS, Ryu HM

  • KMID: 2262487
  • Korean J Obstet Gynecol.
  • 2001 Dec;44(12):2302-2306.
Congenital myotonic dystrophy is a severe and early-onset form of myotonic dystrophy (DM) with a prevalence of 2.5-5.5/100,000 live births. Expansion of the trinucleotide CTG repeat in the 3 untranslated...
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