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Clinical pharmacology review for primary health care providers: II. Steroids

Han S

Primary health care providers play a critical role in maintaining public health, and the appropriate prescription of pharmaceutical products is a major component of their practice. This series of articles...
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Statistical basis for pharmacometrics: maximum likelihood estimator and its asymptotics

Choi K, Yim DS

The maximum likelihood estimator is the point estimator of the top priority in statistical data analysis because of its optimum properties for large sample size. While the maximum likelihood estimator...
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R-based reproduction of the estimation process hidden behind NONMEM(R) Part 1: first-order approximation method

Kim MG, Yim DS, Bae KS

NONMEM(R) is the most-widely used nonlinear mixed effects modelling tool introduced into population PK/PD analysis. Even though thousands of pharmaceutical scientists utilize NONMEM(R) routinely for their data analysis, the various...
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Assessment of statistical power for covariate effects in data from phase I clinical trials

Kim Y, Son H, Son M, Lee D, Heo YA, Park K

One of the important purposes in population pharmacokinetic studies is to investigate the relationships between parameters and covariates to describe parameter variability. The purpose of this study is to evaluate...
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Bioequivalence of the pharmacokinetics between two formulations of 0.2 mg tamsulosin hydrochloride in healthy subjects

Park SI, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH

Tamsulosin is an effective therapeutic option for lower urinary tract symptoms, as it selectively blocks alpha1A- and alpha1D-adrenoceptors in the bladder and prostate. The purpose of this study was to...
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Bioequivalence study of Donepezil hydrochloride in healthy Korean volunteers

Choi Y, Rhee SJ, Jang IJ, Yu KS, Yim SV, Kim BH

Donepezil is a centrally acting, reversible acetylcholinesterase inhibitor that is widely used for treating Alzheimer's disease. This study aimed to compare the pharmacokinetics of Bastia(R), a test tablet formulation of...
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