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A bioequivalence study of two levofloxacin tablets in healthy male subjects

Chung I, Yoon S, Yi S, Kim BH, Yim SV, Jang IJ, Lee H

Levofloxacin is a bactericidal broad spectrum antibiotic against Gram-positive and Gram-negative pathogens. A randomized, two-treatment, two-period, two-way crossover study was conducted to evaluate the bioequivalence of Lectacin 250 mg tablet,...
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Impact of smoking on the effectiveness of TNF-alpha inhibitors in patients with rheumatoid arthritis or Crohn's disease

Song IS, Sohn HS, Kim H, Lim E, Kwon M, Ha JH, Kwon JW

Cigarette smoking may be associated with the augmentation of pro-inflammatory cytokines including Tumor Necrosis Factor-alpha (TNF-alpha), which may affect the outcomes of pharmacological agents such as TNF-alpha inhibitors. The purpose...
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Serotonin transporter occupancy of SKL10406 in humans: comparison of pharmacokinetic-pharmacodynamic modeling methods for estimation of occupancy parameters

Park JS, Lee J, Meyer J, Ilankumaran P, Han S, Yim DS

SKL10406, triple monoamine reuptake inhibitor, is a novel antidepressant candidate. A PET study was performed to investigate the occupancies of serotonin and dopamine transporters (SERT and DAT) in human brain,...
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On comparison of SAS codes with GLM and MIXED for the crossover studies with QT interval data

Choi K, Hong T, Lee J

The structural complexity of crossover studies for bioequivalence test confuses analysts and leaves them a hard choice among various programs. Our study reviews PROC GLM and PROC MIXED in SAS...
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Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in Vietnamese-Koreans

Lim YJ, Cha EY, Jung HE, Ghim JL, Lee SJ, Kim EY, Shin JG

The Vietnamese-Koreans, especially offspring between a Vietnamese mother and a Korean father constituted the highest proportion (64.2%) of total Kosian population according to a census in 2014. To evaluate genetic...
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Geriatric clinical pharmacology and clinical trials in the elderly

Chung JY

The aging process is linked to changes in the physiological function of organs and changes in body composition that alter the pharmacokinetics of drugs and pharmacodynamic responses. Comorbidity and polypharmacy...
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Off-label use and designation of age groupspecific contraindications for pharmacotherapy in children in Korea

Park MS

Children should be treated with medicines that have been tested for efficacy and safety in the given age groups. In reality the majority of drugs being used in children lack...
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Metabolomics 2014 Tenth annual international conference of the metabolomics society

Kim AH, Cho JY

No abstract available.
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Individualization of drug therapy: an historical perspective

Atkinson A

No abstract available.
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History of clinical pharmacology in Korea

Shin SG

No abstract available.
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