- t(12;17)(p13;q12)/TAF15-ZNF384 Rearrangement in Acute Lymphoblastic Leukemia
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Kim J, Kim HS, Shin S, Lee ST, Choi JR
- KMID: 2373567
- Ann Lab Med.
- 2016 Jul;36(4):396-398.
- doi: 10.3343/alm.2016.36.4.396
No abstract available. -
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- Intracellular Antibody Fragment Against Hepatitis B Virus X Protein Does Not Inhibit Viral Replication
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Jin YH, Hong SH, Kim K, Shin HJ, Park S
- KMID: 1381254
- Yonsei Med J.
- 2006 Oct;47(5):721-728.
- doi: 10.3349/ymj.2006.47.5.721
Replication of the hepatitis B virus is suppressed by deficiency of the X protein. Although several molecules that block cellular targets of X protein reduce the production of hepatitis B... -
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- p53-mediated Inhibitory Mechanism on HIV-1 Tat is Likely to be Associated with Tat-Phosphorylation
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Byune HS, Lee SG, Bae YS
- KMID: 1940944
- J Korean Soc Virol.
- 1998 Mar;28(1):39-52.
HIV-1 tat, a strong transactivator, is essential for the HIV-1 replication and AIDS progression. The Tat function is markedly inhibited by human anti-oncogene p53. This work was initiated to identify... -
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- Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma
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Park NH, Song IH, Chung YH
- KMID: 2167163
- Gut Liver.
- 2007 Dec;1(2):101-117.
Hepatocellular carcinoma (HCC) is one of the most frequent and malignant diseases worldwide. Epidemiological studies have clearly demonstrated that chronic hepatitis B virus (HBV) infection is a major etiological factor... -
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- Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
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Lee MJ, Jin YH, Kim K, Choi Y, Kim HC, Park S
- KMID: 2150671
- Immune Netw.
- 2010 Aug;10(4):126-134.
- doi: 10.4110/in.2010.10.4.126
BACKGROUND: CD8+ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8+ T cell response may be one of the major factors leading to... -
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- Inhibition of hepatitis B virus replication by RNA interference
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Park YG
- KMID: 1776809
- Korean J Hepatol.
- 2009 Mar;15(1):1-6.
- doi: 10.3350/kjhep.2009.15.1.1
No abstract available. -
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- Sepsis Mortality in CIITA Deficient Mice is Associated with Excessive Release of High-mobility Group Box 1
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Kim JY, Kim JH, Seo JN, Oh KI
- KMID: 1484312
- Immune Netw.
- 2008 Jun;8(2):39-45.
- doi: 10.4110/in.2008.8.2.39
BACKGROUND: Down regulation of major histocompatibility complex class II transactivator (CIITA) has been identified as a major factor of immunosuppression in sepsis and the level of CIITA expression inversely correlates... -
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- Mapping of Human Cytomegalovirus IE1 Responsive Elements in the c-jun Promoter
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Kim DJ, Kim JH, Choi SB, Han TH, Park CG, Hwang ES, Cha CY
- KMID: 1551995
- J Korean Soc Virol.
- 1998 Sep;28(3):267-274.
Human cytomegalovirus (HCMV) has the ability to activate the espremission of many viral and cellular genes. Among various viral proteins, the immediate early proteins (IE1-72kDa, IE2-86kDa) have been known to... -
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- Dissecting the molecular mechanism of nuclear receptor action: transcription coactivators and corepressors
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Lee JW, Cheong JH, Lee YC, Na SY, lee SK
- KMID: 1109302
- Exp Mol Med.
- 2000 Jun;32(2):53-60.
No abstract available. -
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- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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- Enhanced CEA-specific Immune Responses by Tat-LLO Fusion Protein
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Yi SA, Sohn HJ, Kim CH, Park MY, Oh ST, Kim TG
- KMID: 2150613
- Immune Netw.
- 2005 Sep;5(3):172-178.
- doi: 10.4110/in.2005.5.3.172
BACKGROUND: Carcinoembryonic antigen (CEA) is well-known soluble tumor marker frequently detectable in peripheral blood of carcinoma patients and considered as good target for antigen-specific immunotherapy. However, it is known that... -
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- Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
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Akbarin MM, Shirdel A, Bari A, Mohaddes S, Rafatpanah H, Karimani E, Etminani K, Golabpour , Torshizi R
- KMID: 2413327
- Blood Res.
- 2017 Jun;52(2):106-111.
- doi: 10.5045/br.2017.52.21.106
BACKGROUND: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX)... -
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- A Human Immunodeficiency Virus Type 1 (HIV-1) Tat Cofactor Absent in Rodent Cells is a TAR-associated Factor
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Lee IS, Shank PR
- KMID: 1571517
- Immune Netw.
- 2002 Sep;2(3):150-157.
- doi: 10.4110/in.2002.2.3.150
BACKGROUND: Although Tat plays a role as a potent transactivator in the viral gene expression from the Human Immunodeficiency Virus type 1 long terminal repeat (HIV-1 LTR), it does not... -
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- High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription
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Sun Y, Ye Q, Wu M, Wu Y, Zhang C, Yan W
- KMID: 2361551
- Exp Mol Med.
- 2016 Oct;48(10):e264.
- doi: 10.1038/emm.2016.91
This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the... -
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- Hedgehog Related Protein Expression in Breast Cancer: Gli-2 Is Associated with Poor Overall Survival
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Im S, Choi HJ, Yoo C, Jung JH, Jeon YW, Suh YJ, Kang CS
- KMID: 2277455
- Korean J Pathol.
- 2013 Apr;47(2):116-123.
BACKGROUND: The hedgehog (Hh) signaling pathway is known to play a critical role in various malignancies, but its clinicopathologic role in breast cancer is yet to be established. METHODS: Tissue microarray... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells
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Hwang SL, Kwon O, Kim SG, Lee IK, Kim YD
- KMID: 2154244
- Exp Mol Med.
- 2013 May;45(5):e25.
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a... -
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- The Effect of Metformin Treatment on CRBP-I Level and Cancer Development in the Liver of HBx Transgenic Mice
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Kim JH, Alam MM, Park DB, Cho M, Lee SH, Jeon YJ, Yu DY, Kim TD, Kim HY, Cho CG, Lee DH
- KMID: 1500242
- Korean J Physiol Pharmacol.
- 2013 Oct;17(5):455-461.
- doi: 10.4196/kjpp.2013.17.5.455
Retinoids regulate not only various cell functions including proliferation and differentiation but also glucose and lipid metabolism. After we observed a marked up-regulation of cellular retinol-binding protein-I (CRBP-I) in the... -
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- Terminally Differentiating Eosinophils Express Neutrophil Primary Granule Proteins as well as Eosinophil-specific Granule Proteins in a Temporal Manner
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Kim K, Hwang SM, Kim SM, Park SW, Jung Y, Chung IY
- KMID: 2400627
- Immune Netw.
- 2017 Dec;17(6):410-423.
- doi: 10.4110/in.2017.17.6.410
Neutrophils and eosinophils, 2 prominent granulocytes, are commonly derived from myelocytic progenitors through successive stages in the bone marrow. Our previous genome-wide transcriptomic data unexpectedly showed that genes encoding a... -
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- Pro-apoptotic function of hepatitis B virus X protein
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Kim KH
- KMID: 1792589
- Korean J Hepatol.
- 2010 Jun;16(2):112-122.
- doi: 10.3350/kjhep.2010.16.2.112
Infection of hepatitis B virus (HBV) is a main cause of liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Among the HBV-encoded proteins, the HBV X protein (HBx) has... -
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