- A case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed
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Choi HS, Huh CY, Kim SB
- KMID: 2261959
- Korean J Obstet Gynecol.
- 2000 May;43(5):914-917.
Ovarian cancer has the highest mortality rate among gynecologic malignancies in developed countries. Most women present with advanced disease and require a combination of surgery and chemotherapy. One patient presented with recurrent... -
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- Effect of Topotecan in Combication with Other Antitumor Drugs in Vitro
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Lee YS, Lee TH
- KMID: 2083752
- Korean J Gynecol Oncol Colposc.
- 2000 Mar;11(1):83-90.
OBJECTIVES: The aims of this study were to evaluate the interaction of topotecan with adriamycin, etoposide, 5 fluorouracil (5 FU) and mitomycin C in the established four ovarian cancer... -
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- The role of topotecan as second-line chemotherapy in patients with recurrent epithelial ovarian cancer
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Lee HY, Lee JW, Kim WS, Lee SJ, Kim BG, Lee JH, Bae DS
- KMID: 2272652
- Korean J Obstet Gynecol.
- 2005 Aug;48(8):1917-1925.
OBJECTIVE: Topotecan has recently been used as a second-line agent in treatment of advanced ovarian cancer. The aim of the study was to evaluate the response rate and toxicities of... -
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- Study on Measure of Chemosensitivities to Topotecan, Cisplatin and Taxol Theraphy in Ovarian Cancer Cell Lines: Relationship with p53 and bcl-2 Expression and Apoptosis
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Huh CY, Lim MC, Suh BS
- KMID: 2272101
- Korean J Obstet Gynecol.
- 2003 Jul;46(7):1368-1377.
OBJECTIVE: The aim of this study was to evaluate Topotecan-, Cisplatin- and Taxol-induced apoptosis in five human ovarian cell lines as a measure of chemosensitiviy and relationship between apoptosis and... -
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- Acute Respiratory Distress Syndrome after Topotecan Therapy in a Patient with Small Cell Lung Cancer
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Tae JH, Lee JH, Kim YK, Sim YS, Lee KJ, Noh YW, Park JJ, Ryu YJ, Chun EM, Chang JH
- KMID: 2319055
- Tuberc Respir Dis.
- 2008 Aug;65(2):142-146.
Small cell lung cancer is characterized by an aggressive clinical course and a high tendency for early dissemination in spite of a good chemotherapy response. Topotecan is a topoisomerase I... -
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- Combination chemotherapy with topotecan and vincristine for patients with refractory or recurrent small cell lung cancer
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Ahn HS, Won HJ, Lee HR, Yuh YJ, Kim SR
- KMID: 2081281
- Korean J Med.
- 2007 Jun;72(6):632-638.
BACKGROUDN: Small cell lung cancer (SCLC) is a chemotherapy-sensitive tumor. However, the duration of response is usually short and most patients experience relapses. Topotecan is commonly used for treatment of... -
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- Clinical Study of Topotecan as Second-Line Treatment in Small Cell Lung Cancer
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Kim HR, Yang SH, Jeong ET
- KMID: 2425540
- Tuberc Respir Dis.
- 2002 Mar;52(3):230-240.
BACKGROUND: The majority of chemotherapy-treated small cell lung cancers(SCLC) patients eventually recur. Although many patients are in excellent physical condition at the time of recurrence, few drugs or drug comb... -
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- Outcomes of advanced and recurrent cervical cancer treated with cisplatin and generic topotecan: retrospective analysis in a tertiary care hospital in Thailand
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Suprasert , Charoenkwan K, Cheewakriangkrai C
- KMID: 2173547
- J Gynecol Oncol.
- 2010 Dec;21(4):237-240.
- doi: 10.3802/jgo.2010.21.4.237
OBJECTIVE: Retrospective evaluation of the outcome of stage IVB, recurrent or persistent cervical cancer treated with cisplatin and generic topotecan (CT) in a tertiary care hospital in Thailand. METHODS: The medical... -
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- Efficacy of Topotecan as a Second-Line Treatment of Small-Cell Lung Cancer in Patients with Refractory and Sensitive Disease: Retrospective Study
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Park HS, Kim MH, Lee YS, Ahn JY, Kwan SJ, Lee KS, Kang DW, Jung SS, Kim JO, Kim SY
- KMID: 2200194
- J Lung Cancer.
- 2003 Mar;2(1):37-43.
PURPOSE: Chemotherapy is the treatment of choice for small-cell lung cancer (SCLC). Despite the high response rates with first-line therapy, most patients eventually experience disease progression, and finally become candidates... -
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- Clinical Response to Etoposide Plus Carboplatin and Topotecan Chemotherapy in Small Cell Lung Cancer
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Park KH, Cho GJ, Ju JY, Son CY, Wi JO, Kim KS, Kim YI, Lim SC, Kim YC, Park KO
- KMID: 2318414
- Tuberc Respir Dis.
- 2003 Apr;54(4):415-428.
BACKGROUND: This study assessed the efficacy and toxicity of etoposide and carboplatin(EC) combination regimen as a first line therapy for small cell lung cancer(SCLC), and determined the efficacy and toxicity... -
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- Mutation of DNA Mismatch Repair Genes and its Relation to Taxol and Topotecan Chemosensitivity in the Clones from the Cisplatin-Resistant Ovarian Cancer Cell Lines
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Kim HK, Son WS, Park TC, Kim TE, Koh YM, Song JM, Park KY, Kim JH, Ryu KS, Kim JW, NamKoong S, Kim SP
- KMID: 2075936
- Korean J Obstet Gynecol.
- 1999 Nov;42(11):2465-2473.
OBJECTIVE: Ovarian cancer represents a relatively chemosensitive solid tumor, with responsiveness to a range of agents. Cisplatin is the mainstay of drug treatment and is one of the most active... -
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- Phase II Study of Topotecan and Etoposide as Second-line Treatment in Chemotherapy-refractory Small-cell Lung Cancer
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Kim C, Sohn JH, Kim JH, Kim SK, Kim YS, Chang J, Cho JY
- KMID: 1972937
- Cancer Res Treat.
- 2002 Oct;34(5):334-338.
PURPOSE: Refractory small-cell lung cancer (SCLC) has a poor prognosis, and current salvage chemotherapy for refractory SCLC, such as CAV (cyclophosphamide, adriamycin, vincristine) or topotecan, has an unsatisfactory outcome, with... -
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- Topotecan/CycophosphamideSalvage Chemotherapy in Children with Recurrent or Refractory Solid Tumors
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Kim ES, Jung HJ, Park JE
- KMID: 2007196
- Clin Pediatr Hematol Oncol.
- 2009 Oct;16(2):122-129.
PURPOSE: To review the effect of the topotecan/cyclophosphamide (TOPO/CPM) salvage chemotherapy in children who were treated for recurrent or refractory solid tumors in our hospital. METHODS: We analyzed the medical records... -
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- Phase II Study to Topotecan and Cisplatin in Advanced Hepatocellular Carcinoma
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Lee GY, Kim BS, Seo YT, Choi SH, Kim HJ, Choi DS, Ko JY, Yang SH, Byun JH
- KMID: 1106144
- Korean J Intern Med.
- 2003 Jun;18(2):104-108.
BACKGROUND: Hepatocellular carcinoma remains a highly chemoresistant neoplasm and is a common malignancy with poor prognosis in Korea. We performed a phase II study to evaluate the efficacy and toxicities... -
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- In Vitro Interaction of Taxol with Other Antitumor Drugs in the Established Choriocarcinoma Cell Lines
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Kim PJ, Lim HC, Kim DW, Lee YS
- KMID: 2272224
- Korean J Obstet Gynecol.
- 2004 Jan;47(1):76-82.
OBJECTIVE: Taxol (Bristol-Myers Squibb)(paclitaxel) has been shown to be a potent inhibitor of cell growth for a variety of tumors. The aim of this study was to evaluate the interaction... -
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- The correlation of clusterin binding affinity to chemotherapeutic agents with chemoresistance in ovarian cancer cells
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Choi JH, Suh MJ, Park DC
- KMID: 2077891
- Korean J Obstet Gynecol.
- 2008 Jul;51(7):738-743.
OBJECTIVE: The purpose of this study was to determine the mechanism of action of clusterin?known as a chemo-resistance protein?by analyzing its binding with chemotherapeutic agents and elucidating its relation with... -
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- The efficacy and toxicity of topotecan in combination with platinum in patients with recurrent epithelial ovarian cancer and primary peritoneal carcinomatosis
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You HJ, Kim YM, Lee SW, Lee JN, Kim DY, Suh DS, Kim JH, Kim YT, Nam JH, Mok JE
- KMID: 2273197
- Korean J Obstet Gynecol.
- 2008 Jan;51(1):31-40.
OBJECTIVE: The aim of this study was to evaluate the efficacy and toxicity of topotecan, camptothecin analogue topoisomerase I inhibitor, as the combination therapy with platinum in patients with recurrent... -
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- Long-term survival after intraperitoneal chemotherapy with paclitaxel-cisplatin for recurrent primary peritoneal cancer resistant to multiple lines of intravenous chemotherapy
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Hue H, Kim K, Kim H, Suh DH, No JH, Kim YB
- KMID: 2451659
- Obstet Gynecol Sci.
- 2019 Jul;62(4):285-289.
- doi: 10.5468/ogs.2019.62.4.285
The long-term survival of heavily pretreated patients with primary peritoneal cancer (PPC) is uncommon. Here, we report on a patient with PPC refractory to multiple lines of intravenous chemotherapy, namely,... -
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- Topotecan, Cyclophosphamide, Etoposide in the Treatment of Recurrent or Refractory Solid Tumors in Children
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Han YJ, Lee JW, Kim H, Kim NH, Song ES, Kang HJ, Park KD, Shin HY, Ahn HS
- KMID: 2168946
- Clin Pediatr Hematol Oncol.
- 2010 Oct;17(2):180-187.
PURPOSE: We investigated the results of topotecan, cyclophosphamide, etoposide (TCE) salvage chemotherapy for children with recurrent or refractory solid tumors to find out suitable therapeutic indications. METHODS: We analyzed medical records... -
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- Topotecan-based combination chemotherapy in patients with transformed chronic myelogenous leukemia and advanced myelodysplastic syndrome
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Park SJ, Kim DW, Kim HJ, Eom HS, Min CK, Lee JW, Min WS, Kim CC
- KMID: 759504
- Korean J Intern Med.
- 2000 Jul;15(2):122-126.
BACKGROUND: Patients with transformed chronic myelogenous leukemia(CML) and advanced myelodysplastic syndrome(MDS) have poor prognosis. The aim of this study is to evaluate the feasibility of second chronic phase... -
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