- Simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX, in human plasma by liquid chromatography-tandem mass spectrometry: Applications in steady-state pharmacokinetics in patients
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Chae SU, Min KL, Lee CB, Huang Z, Chang MJ, Bae SK
- KMID: 2458949
- Transl Clin Pharmacol.
- 2019 Sep;27(3):98-106.
- doi: 10.12793/tcp.2019.27.3.98
A sensitive and simple liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous quantification of ticagrelor and its active metabolite, AR-C124910XX from 50 µL human plasma using... -
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- Effects of K+ channel modulators on extracellular K+ accumulation during ischemia in the rat hippocampal slice
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Choi JK, Chun BG, Ryu PD
- KMID: 2285186
- Korean J Physiol Pharmacol.
- 1997 Dec;1(6):681-690.
Loss of synaptic transmission and accumulation of extracellular K+((K+)o) are the key features in ischemic brain damage. Here, we examined the effects of several K+ channel modulators on the early ischemic changes in... -
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- A Portulaca oleracea L. extract promotes insulin secretion via a Kâº(ATP) channel dependent pathway in INS-1 pancreatic β-cells
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Park JE, Han JS
- KMID: 2442291
- Nutr Res Pract.
- 2018 Jun;12(3):183-190.
- doi: 10.4162/nrp.2018.12.3.183
BACKGROUND/OBJECTIVE: This study was designed to investigate how a Portulaca oleracea L. extract (POE) stimulates insulin secretion in INS-1 pancreatic β-cells. MATERIALS/METHOD: INS-1 pancreatic β-cells were incubated in the presence of... -
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