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Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression

Hur JH, Park MJ, Park IC, Yi DH, Rhee CH, Hong SI, Lee SH

To evaluate possible roles of matrix metalloproteinase (MMP)-1, -2, tissue inhibitor of metalloproteinase (TIMP)-1, -2 and membrane-type-1 matrix metalloproteinase (MT1-MMP) in invasion of human gliomas, expressions of these proteins were...
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Expression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma

Joo YE, Seo YH, Lee WS, Kim HS, Choi SK, Rew JS, Park CS, Kim SJ

  • KMID: 759515
  • Korean J Intern Med.
  • 2000 Dec;15(3):171-178.
BACKGROUND: Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and...
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Role of tissue inhibitors of metalloproteinases (TIMPs) in colorectal carcinoma

Joo YE, Seo KS, Kim J, Kim HS, Rew JS, Park CS, Kim SJ

Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial...
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Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer

Ko BK, Cho HR, Choi DW, Nam CW, Park CJ, Kim GY, Kim SS, Woo YJ, Huh J, Kim MY

The matrix metalloproteinases (MMPs) have been associated with tumor cell invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes and their...
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Expression of integrins, cyclooxygenases and matrix metalloproteinases in three-dimensional human endometrial cell culture system

Yang H, Han S, Kim H, Choi YM, Hwang KJ, Kwon HC, Kim SK, Cho DJ

  • KMID: 1093601
  • Exp Mol Med.
  • 2002 Mar;34(1):75-82.
The objective of this investigation was to establish a three-dimensionally cultured human endometrium which could be used as a tissue model for the mechanism study of implantation in vitro. By...
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Overexpression of tissue inhibitors of metalloproteinase-1 and -2 in the stroma of gastric cancer

Hong SI, Park IC, Hong WS, Son YS, Lee SH, Lee JI, Choi DW, Moon NM, Choe TB, Jang JJ

The fundamental event of cancer invasion and metastasis is the complicated interaction of cancer cells with host cells, in which event, a number of proteases and their inhibitors are involved....
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