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Mesenchymal Stem Cell Spheroids: A Promising Tool for Vascularized Tissue Regeneration

Kang Y, Na J, Karima G, Amirthalingam S, Hwang NS, Kim HD

BACKGROUND Mesenchymal stem cells (MSCs) are undifferentiated cells that can differentiate into specific cell lineages when exposed to the right conditions. The ability of MSCs to differentiate into particular cells...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives

Thangam T, Parthasarathy K, Supraja K, Haribalaji V, Sounderrajan V, Rao SS, Jayaraj S

Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and physiology of human organs. A few of the present applications of organoids...
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LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway

Wu X, Fu Y, Ma J, Li C, He A, Zhang T

BACKGROUND: Tissue engineering is increasingly viewed as a promising avenue for functional cartilage reconstruction. However, chondrocyte dedifferentiation during in vitro culture remains an obstacle for clinical translation of tissue engineered cartilage....
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Exploring the Cocktail Factor Approach to Generate Salivary Gland Progenitors through Co-Culture Techniques

Zhang Y, Yan S, Mei Z, Zhang H, Ding C, Zhang S, Wei S

BACKGROUND: The derivation of salivary gland (SG) progenitors from pluripotent stem cells (PSCs) presents significant potential for developmental biology and regenerative medicine. However, the existing protocols for inducing SG include...
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Human Nasal Inferior Turbinate-Derived Neural Stem Cells Improve the Niche of Substantia Nigra Par Compacta in a Parkinson’s Disease Model by Modulating Hippo Signaling

Choi J, Park SW, Lee H, Kim DH, Kim SW

BACKGROUND: Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases, following Alzheimer’s disease. The onset of PD is characterized by the loss of dopaminergic neurons in the substantia...
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Characterization of Gold-Enhanced Titania: Boosting Cell Proliferation and Combating Bacterial Infestation

Amna T, Hassan MS, Algethami JS, Aljuaid A, Alfarsi A, Alnefaie R, Sheikh FA, Khil MS

BACKGROUND: In this study an approach was made to efficaciously synthesize gold enhanced titania nanorods by electrospinning. This study aims to address effects of gold enhanced titania nanorods on muscle...
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Therapeutic Effect of Schwann Cell-Like Cells Differentiated from Human Tonsil-Derived Mesenchymal Stem Cells on Diabetic Neuropathy in db/db Mice

Yum Y, Park S, Nam YH, Yoon J, Song H, Kim HJ, Lim J, Jung SC

BACKGROUND: Diabetic neuropathy (DN) is the most common complication of diabetes, and approximately 50% of patients with this disease suffer from peripheral neuropathy. Nerve fiber loss in DN occurs due...
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Reducing Nogo-B Improves Hepatic Fibrosis by Inhibiting BACe1-Mediated Autophagy

Gao L, Zhuang Y, Liu Z

BACKGROUND: Hepatic fibrosis (HF) is a histopathological change in the process of long-term liver injury caused by cytokine secretion and internal environment disturbance, resulting in excessive liver repair and fiber...
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Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development

Youn KI, Lee JW, Song Y, Lee SY, Song KH

BACKGROUND: Various cell culture platforms that could display native environmental cue-mimicking stimuli were developed, and effects of environmental cues on cell behaviors were studied with the cell culture platforms. Likewise,...
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Efficacy and Safety Evaluation of Tacrolimus-Eluting Stent in a Porcine Coronary Artery Model

Park DS, Na MH, Jeong MH, Sim DS, Jin YJ, Kee HJ, Kim MK, Kim JH, Hong YJ, Cho KH, Hyun DY, Oh S, Lim KS, Byeon DH, Kim JH

BACKGROUND: A drug-eluting stent (DES) is a highly beneficial medical device used to widen or unblock narrowed blood vessels. However, the drugs released by the implantation of DES may hinder...
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