Tissue Eng Regen Med.
2024 Jul;21(5):711-721. 10.1007/s13770-024-00630-8.
Characterization of Gold-Enhanced Titania: Boosting Cell Proliferation and Combating Bacterial Infestation
- Affiliations
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- 1Department of Biology, Faculty of Science, Al-Baha University, P.O. Box 1988, 65799 Al-Baha, Saudi Arabia
- 2Department of Chemistry, Faculty of Science, Al-Baha University, P.O. Box 1988, 65799 Al-Baha, Saudi Arabia
- 3Department of Chemistry, Faculty of Science, Al-Baha University, P.O. Box 1988, 65799 Al-Baha, Saudi Arabia
- 4Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, 11001 Najran, Saudi Arabia
- 5Department of Biology, College of Science and Humanities, Shaqra University, Shaqra, Saudi Arabia
- 6Nanostructured and Biomimetic Lab, Department of Nanotechnology, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir 190006, India
- 7Department of Organic Materials and Textile Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea
- KMID: 2557866
- DOI: http://doi.org/10.1007/s13770-024-00630-8
Abstract
- BACKGROUND
In this study an approach was made to efficaciously synthesize gold enhanced titania nanorods by electrospinning. This study aims to address effects of gold enhanced titania nanorods on muscle precursor cells. Additionally, implant related microbial infections are prime cause of various disastrous diseases. So, there is predictable demand for synthesis of novel materials with multifunctional adaptability.
METHODS
Herein, gold nanoparticles were attached on titania nanorods and described using many sophisticated procedures such as XRD, SEM, EDX and TEM. Antimicrobial studies were probed against Gram-negative Escherichia coli. C2C12 cell lines were exposed to various doses of as-prepared gold enhanced titania nanorods in order to test in vitro cytotoxicity and proliferation. Cell sustainability was assessed through Cell Counting Kit–8 assay at regular intervals. A phase-contrast microscope was used to examine morphology of exposed C2C12 cells and confocal laser scanning microscope was used to quantify cell viability.
RESULTS
The findings indicate that titania nanorods enhanced with gold exhibit superior antimicrobial efficacy compared to pure titania. Furthermore, newly synthesized gold-enhanced titania nanorods illustrate that cell viability follows a time and concentration dependent pattern.
CONCLUSION
Consequently, our study provides optimistic findings indicating that titania nanorods adorned with gold hold significant potential as foundational resource for developing forthcoming antimicrobial materials, suitable for applications both in medical and biomedical fields. This work also demonstrates that in addition to being extremely biocompatible, titania nanorods with gold embellishments may be used in a range of tissue engineering applications in very near future.
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