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Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration

Zhao J, Lu F, Dong Z

BACKGROUND: Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue engineering (ATE) provides a promising way to solve this problem. METHODS: This...
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Advancements in Human Embryonic Stem Cell Research: Clinical Applications and Ethical Issues

Park SJ, Kim YY, Han JY, Kim SW, Kim H, Ku SY

BACKGROUND: The development and use of human embryonic stem cells (hESCs) in regenerative medicine have been revolutionary, offering significant advancements in treating various diseases. These pluripotent cells, derived from early...
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Modulation of Inflammatory Responses to Enhance Nerve Recovery after Spinal Cord Injury

Seo YK

Inflammation can occur at the wound site, and immune cells are necessary to trigger wound healing and tissue regeneration after injury. It is partly initiated by the rapid migration of...
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Efficacy of IFN-γ-Primed Umbilical Cord-Derived Mesenchymal Stem Cells on Temporomandibular Joint Osteoarthritis

Kim H, Kim Y, Yun SY, Lee BK

BACKGROUND: Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease affecting the cartilage and subchondral bone, leading to temporomandibular joint pain and dysfunction. The complex nature of TMJOA warrants effective alternative...
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α-Gal Nanoparticles in CNS Trauma: I. In Vitro Activation of Microglia Towards a Pro-Healing State

Gopalakrishnan B, Galili U, Dunbar A, Solorio L, Shi R, Li J

BACKGROUND: Macrophages and microglia play critical roles after spinal cord injury (SCI), with the pro-healing, antiinflammatory (M2) subtype being implicated in tissue repair. We hypothesize that promoting this phenotype within...
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Fabricating Composite Cell Sheets for Wound Healing: Cell Sheets Based on the Communication Between BMSCs and HFSCs Facilitate Full-Thickness Cutaneous Wound Healing

Li G, Wang Q, Liu H, Yang Z, Wu Y, He L, Deng X

BACKGROUND: Insufficient angiogenesis and the lack of skin appendages are critical challenges in cutaneous wound healing. Stem cell-fabricated cell sheets have become a promising strategy, but cell sheets constructed by...
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Exosomes Secreted During Myogenic Differentiation of Human Fetal Cartilage-Derived Progenitor Cells Promote Skeletal Muscle Regeneration through miR-145-5p

Shin DI, Jin YJ, Noh S, Yun HW, Park DY, Min BH

BACKGROUND: Currently, there is no apparent treatment for sarcopenia, which is characterized by diminished myoblast function. We aimed to manufacture exosomes that retain the myogenic differentiation capacity of human fetal...
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Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism

Jäger J, Vahav I, Thon M, Waaijman T, Spanhaak B, Kok Md, Bhogal RK, Gibbs S, Koning JJ

BACKGROUND: Dysregulation of skin metabolism is associated with a plethora of diseases such as psoriasis and dermatitis. Until now, reconstructed human skin (RhS) models lack the metabolic potential of native...
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α-Gal Nanoparticles in CNS Trauma: II. Immunomodulation Following Spinal Cord Injury (SCI) Improves Functional Outcomes

Gopalakrishnan B, Galili U, Saenger M, Burket NJ, Koss W, Lokender MS, Wolfe KM, Husak SJ, Stark CJ, Solorio L, Cox A, Dunbar A, Shi R, Li J

BACKGROUND: Previous investigations have shown that local application of nanoparticles presenting the carbohydrate moiety galactose-a-1,3-galactose (α-gal epitopes) enhance wound healing by activating the complement system and recruiting pro-healing macrophages to...
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An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function

Morrison AI, Mikula AM, Spiekstra SW, Kok Md, Affandi AJ, Roest HP, Laan LJWvd, Winde CMd, Koning JJ, Gibbs S, Mebius RE

BACKGROUND: Human lymph node (HuLN) models have emerged with invaluable potential for immunological research and therapeutic application given their fundamental role in human health and disease. While fibroblastic reticular cells...
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