- Thrombospondin-1 and -2 Expressions in Hepatocellular Carcinomas: an Association with Tumor Angiogenesis and p53 Overexpression
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Chung JS, Park HS, Son HJ, Kang MJ, Moon WS
- KMID: 1855942
- Korean J Pathol.
- 2005 Aug;39(4):215-221.
Background : It has been suggested that thrombospondin (TSP) is a p53-dependent negative regulator of tumor angiogenesis. TSP expression and localization in hepatocellular carcinomas (HCCs) and its association with overexpression... -
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- Purification of thrombospondin receptor (CD36) from human platelet membrane
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Kim JH, Suk KH, Park NY, Kim SH
- KMID: 2128623
- Exp Mol Med.
- 1997 Mar;29(1):31-34.
Thrombospondin receptor (CD36) has been recently identified in platelets and various cell lines as the receptor for thrombospondin, an adhesive protein required for irreversible aggregation of platelets as well as... -
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- A Splenectomy in Plasma Exchange Refractory Thrombotic Thrombocytopenia Purpura
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Lee YJ, Shim H, Park DE
- KMID: 2238902
- Korean J Lab Med.
- 2006 Apr;26(2):119-122.
- doi: 10.3343/kjlm.2006.26.2.119
Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, and variable abnormalities in renal function and mental status. The pathogenesis of TTP is related to an inhibitor... -
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- mRNA Expression of Thrombospondin-1 and -2 in Severe Endometriosis Patients in Korean Women
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Hur SE, Lee JY, Moon HS, Chung HW
- KMID: 1864688
- Korean J Fertil Steril.
- 2005 Sep;32(3):253-260.
OBJECTIVE: We investigated the expression of TSP-1 and -2 in eutopic endometrium of advanced endometriosis and control patients. METHODS: The 33 endometriosis patients and 32 controls were enrolled. Endometrial samples were... -
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- Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure
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Pyun JA, Kim S, Kwack K
- KMID: 1805494
- Clin Exp Reprod Med.
- 2014 Sep;41(3):120-124.
- doi: 10.5653/cerm.2014.41.3.120
OBJECTIVE: The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated... -
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- Changes in VWF-cleaving Metalloprotease (ADAMTS 13) activity in the thrombotic microangiopathy after kidney tranplantation
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Lee YG, Kim KH, Cheon SC, Hwang IJ, Yang DH, Oh D, Kim KS
- KMID: 1927316
- Korean J Med.
- 2004 Nov;67(Suppl 3):S814-S820.
The thrombotic microangiopathy associated with cyclosporine A after kidney transplantation is a detrimental complication that could lead to the loss of transplanted kidney. Although the pathogenesis is still unclear, the... -
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- Differential Diagnosis and Treatment of Thrombotic Microangiopathy Syndrome
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Hong J
- KMID: 2438029
- Korean J Med.
- 2019 Feb;94(1):83-88.
- doi: 10.3904/kjm.2019.94.1.83
Diagnosis of thrombotic microangiopathy (TMA) is challenging due to its close association with other forms of microangiopathic hemolytic anemia, such as malignant hypertension and disseminated intravascular coagulation, and because other... -
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- Type 3 Repeats of Thrombospondin-2 Increases Metastasis in Mouse Colorectal Cancer CT-26 Cells
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Jin Z, Kim YJ, Park YK, Choi YD, Lee JH, Lee D, Choi CY, Juhng SW, Choi C
- KMID: 2172251
- Chonnam Med J.
- 2010 Apr;46(1):7-18.
- doi: 10.4068/cmj.2010.46.1.7
Thrombospondins (TSPs) are secreted multimeric glycoproteins that modulate extracellular matrix structure and cell behaviour. TSPs are involved in platelet aggregation, cell adhesion, migration, angiogenesis, wound healing, and proliferation. The purpose... -
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- Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth
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Yoo JY, You YA, Kwon EJ, Park MH, Shim S, Kim YJ
- KMID: 2426021
- Obstet Gynecol Sci.
- 2018 Sep;61(5):565-574.
- doi: 10.5468/ogs.2018.61.5.565
OBJECTIVE: This study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion. METHODS: We examined the association between differentially methylated regions (DMRs) and differentially expressed genes... -
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- Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee
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Kang BJ, Ryu J, Lee CJ, Hwang SC
- KMID: 2170642
- Biomol Ther.
- 2014 May;22(3):239-245.
We investigated whether luteolin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as production of MMP-3 in the rat... -
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- Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
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Park JS, Lee HJ, Lee DY, Jo HS, Jeong JH, Kim DH, Nam DC, Lee CJ, Hwang SC
- KMID: 2380293
- Biomol Ther.
- 2015 Sep;23(5):442-448.
- doi: 10.4062/biomolther.2015.045
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as... -
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- A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation
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Choi JY, Lee JW, Ju HY, Hong CR, Kim H, Lee DS, Kim NH, Kang HJ, Park KD, Shin HY
- KMID: 2279824
- Clin Pediatr Hematol Oncol.
- 2014 Oct;21(2):140-144.
- doi: 10.0000/cpho.2014.21.2.140
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report... -
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- Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo
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Nam DC, Kim BK, Lee HJ, Shin HD, Lee CJ, Hwang SC
- KMID: 2388679
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):221-228.
- doi: 10.4196/kjpp.2016.20.2.221
We investigated whether prunetin affects the proteolytic activity, secretion, and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3... -
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- Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
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Park JS, Kim DK, Shin HD, Lee HJ, Jo HS, Jeong JH, Choi YL, Lee CJ, Hwang SC
- KMID: 2170528
- Biomol Ther.
- 2016 Mar;24(2):163-170.
- doi: 10.4062/biomolther.2015.217
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in... -
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- Clinical Significance of von Willebrand Factor-Cleaving Protease (ADAMTS13) Deficiency in Patients with Sepsis-Induced Disseminated Intravascular Coagulation
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Kim YK, Lee J, Lee KA, Kwon HU
- KMID: 2170254
- Infect Chemother.
- 2009 Apr;41(2):78-81.
- doi: 10.3947/ic.2009.41.2.78
BACKGROUND: Deficiency of von Willebrand factor-cleaving protease, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13), is thought to be responsible for platelet aggregation and microthrombi formation, which... -
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- A Disintegrin and Metalloprotease with Thrombospondin Motif 2 May Contribute to Cirrhosis in Humans through the Transforming Growth Factor-beta/SMAD Pathway
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Dong C, Li HJ, Chang S, Liao HJ, Zhang ZP, Huang P, Tang HH
- KMID: 2135073
- Gut Liver.
- 2013 Mar;7(2):213-220.
BACKGROUND/AIMS: We aimed to investigate the correlation between a disintegrin and metalloprotease with thrombospondin motif 2 (ADAMTS-2) and transforming growth factor-beta1 (TGF-beta1) in clinical human cirrhotic tissues. METHODS: The liver tissues... -
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- Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat
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Ra HJ, Lee HJ, Jo HS, Nam DC, Lee YB, Kang BH, Moon DK, Kim DH, Lee CJ, Hwang SC
- KMID: 2371064
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):19-26.
- doi: 10.4196/kjpp.2017.21.1.19
We investigated whether betulin affects the gene expression, secretion and proteolytic activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3... -
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- Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
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Kang DG, Lee HJ, Kim KT, Hwang SC, Lee CJ, Park JS
- KMID: 2371038
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):197-204.
- doi: 10.4196/kjpp.2017.21.2.197
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well... -
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- Gene Expression in the Capsule Tissue of the Frozen Shoulder
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Kim JM, Kim YS, Ji JH, Lee JY, Yoo HH, Lee YK
- KMID: 2185596
- J Korean Orthop Assoc.
- 2010 Feb;45(1):65-72.
- doi: 10.4055/jkoa.2010.45.1.65
PURPOSE: To investigate the overall expression of extracellular matrix (ECM) and adhesion molecule genes using a gene array technique in the joint capsule of a frozen shoulder. MATERIALS AND METHODS: Tissues... -
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- Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
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Kang DG, Lee HJ, Lee CJ, Park JS
- KMID: 2427509
- Biomol Ther.
- 2018 Nov;26(6):560-567.
- doi: 10.4062/biomolther.2018.132
In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B (NF-κB) in articular chondrocytes. Rabbit articular chondrocytes were... -
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