- Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2
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Kang JH, Kim HJ, Park MK, Lee CH
- KMID: 2395812
- Biomol Ther.
- 2017 Nov;25(6):625-633.
- doi: 10.4062/biomolther.2016.228
Sphingosylphosphorylcholine (SPC) is one of the bioactive phospholipids that has many cellular functions such as cell migration, adhesion, proliferation, angiogenesis, and Ca²⺠signaling. Recent studies have reported that SPC induces... -
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- Inhibition of Angiogenesis by the First Type I Repeat Peptides of Thrombospondin-1
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Yoo BI, Jeong GB
- KMID: 2150440
- Korean J Phys Anthropol.
- 2015 Dec;28(4):223-238.
- doi: 10.11637/kjpa.2015.28.4.223
Angiogenesis is the fundamental biological phenomenon in the development of vertebrates and various pathophysiological process such as cancer, inflammation and wound healing. Thrombospondin-1 is a well-known anti-angiogenic molecule which is... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus
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Choi KY, Kim DB, Kim MJ, Kwon BJ, Chang SY, Jang SW, Cho EJ, Rho TH, Kim JH
- KMID: 1826381
- Korean Circ J.
- 2012 Feb;42(2):100-106.
- doi: 10.4070/kcj.2012.42.2.100
BACKGROUND AND OBJECTIVES: Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated... -
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- Thrombospondin-1 and -2 Expressions in Hepatocellular Carcinomas: an Association with Tumor Angiogenesis and p53 Overexpression
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Chung JS, Park HS, Son HJ, Kang MJ, Moon WS
- KMID: 1855942
- Korean J Pathol.
- 2005 Aug;39(4):215-221.
Background : It has been suggested that thrombospondin (TSP) is a p53-dependent negative regulator of tumor angiogenesis. TSP expression and localization in hepatocellular carcinomas (HCCs) and its association with overexpression... -
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- The Effect of Endocrine Therapy on Angiogenesis and the Expression of Thrombospondin-1 and Vascular Endothelial Growth Factor in Prostate Cancer
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Kwak C, Jeong H, Byun SS, Baek M, Kim C, Kim T, Lee SE
- KMID: 2292617
- Korean J Urol.
- 2002 May;43(5):372-379.
PURPOSE: The exact role of angiogenesis in prostate cancer is unknown. We investigated whether endocrine therapy inhibits angiogenesis, and influences the expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis,... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 mRNA Related to Microvessel Density in Invasive Cervical Carcinomas
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Lee JE, Lee SK, Chi SG
- KMID: 2272998
- Korean J Obstet Gynecol.
- 2006 Dec;49(12):2573-2582.
OBJECTIVE: Vascular Endothelial Growth Factor (VEGF) is a potent stimulator of angiogenesis in solid tumors. Thrombospondin-1 (TSP-1) has inhibitory role in cancer cell proliferation and metastasis. To analyze the correlation... -
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- The Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in Wilms' Tumor
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Jeong SJ, Park EC, Kwak C, Jin RJ, Lee SE, Choi H
- KMID: 2292344
- Korean J Urol.
- 2001 Mar;42(3):265-272.
PURPOSE: With the process of neoangiogenesis being linked to the growth and metastasis of various tumors, anticancer therapeutics with a basis in the suppression of neoangiogenesis has recently... -
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- Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers
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Suh EJ, Kabir MH, Kang UB, Lee JW, Yu J, Noh DY, Lee C
- KMID: 1120140
- Exp Mol Med.
- 2012 Jan;44(1):36-44.
- doi: 10.3858/emm.2012.44.1.003
Breast cancer is the most common cancer in women worldwide. It is necessary to identify biomarkers for early detection, to make accurate prognoses, and to monitor for any recurrence of... -
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- The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells
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Ryu GR, Kang JH, Hong KJ, Jeong IK, Jang HI, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ
- KMID: 2200845
- J Korean Soc Endocrinol.
- 2006 Aug;21(4):302-310.
- doi: 10.3803/jkes.2006.21.4.302
BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis.... -
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- Changes of Gene Expression in NIH3T3 Cells Exposed to Osmotic and Oxidative Stresses
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Lee JS, Jung JH, Kim TH, Seo JS
- KMID: 2166167
- Genomics Inform.
- 2004 Jun;2(2):67-74.
Cells consistently face stressful conditions, which cause them to modulate a variety of intracellular processes and adapt to these environmental changes via regulation of gene expression. Hyperosmotic and oxidative stresses... -
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- Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
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Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ
- KMID: 938874
- Exp Mol Med.
- 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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- KCl Mediates K+ Channel-Activated Mitogen-Activated Protein Kinases Signaling in Wound Healing
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Shim JH, Lim JW, Kim BK, Park SJ, Kim SW, Choi TH
- KMID: 2267588
- Arch Plast Surg.
- 2015 Jan;42(1):11-19.
- doi: 10.5999/aps.2015.42.1.11
BACKGROUND: Wound healing is an interaction of a complex signaling cascade of cellular events, including inflammation, proliferation, and maturation. K+ channels modulate the mitogen-activated protein kinase (MAPK) signaling pathway. Here,... -
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- TSP-1 mRNA Expression in Invasive Cervical Cancer: Correlate with Angiogenesis and Clinicopathological Features
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Kim YH, Lee SK, Chi SG, Lee JH, Kim SB
- KMID: 2272188
- Korean J Obstet Gynecol.
- 2003 Nov;46(11):2170-2179.
OBJECTIVE: Acquisition of a proangiogenic environment is essential to the cervical cancer growth, invasion and metastasis, and the angiogenic phenotype in cervical cancer is strongly associated with clinical outcome. However,... -
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- Expression analysis of mRNA and proteins related to angiogenesis following management with cytotoxic agents in gynecologic cancer cell lines
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Kim YJ, Kong MS, Lee YM, Chang SY, Kim SR, Kim KT, Hwang YY, Cho SH
- KMID: 1870358
- Korean J Obstet Gynecol.
- 2007 Mar;50(3):476-485.
OBJECTIVE: Angiogenesis is central role to both the proliferation and metastasis of malignant tumor. The intense interest in angiogenesis has also lead to a re-examination of the activity of established... -
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- The Influence of Angiogeneic Gene Expression Following Management with Antineoplastic Agents to the Apoptosis of Malignant Tumor Cell
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Kim YJ, Lee YY, Lee YM, Chang SY, Kim SR, Kim KT, Hwang YY, Cho SH, Ryu KY
- KMID: 2083839
- Korean J Gynecol Oncol Colposc.
- 2004 Sep;15(3):192-203.
OBJECTIVE: We evaluated the alteration in the expression of the genes which are related to the angiogenesis in tumor bed following the management with antineoplstic agents to the various gynecologic... -
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