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Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis

Okuda A, Ogura T, Imanishi M, Miyano A, Nishioka N, Higuchi K

BACKGROUND/AIMS: Recently, recombinant human soluble thrombomodulin (rTM) has been developed as a new drug for disseminated intravascular coagulation (DIC). This study aims to evaluate the clinical benefit of rTM in...
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A Case of Metastatic Cancer of the Penis from Urinary Bladder Carcinoma

Park EJ, Jeon HJ, Bang HD, Kim KH, Kim KJ

  • KMID: 2250232
  • Korean J Dermatol.
  • 2003 Apr;41(4):530-532.
Despite abundant blood supply, metastatic tumors of the penis are rare. We report herein a case of metastatic cancer of the penis from urinary bladder carcinoma in a 80-year-old man....
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Immunohistochemical Study of Thrombomodulin in Experimental Cholesteatoma

Park KH, Park HJ, Lee JS, Eum JH

  • KMID: 1977712
  • Korean J Otolaryngol-Head Neck Surg.
  • 1999 Nov;42(11):1349-1352.
BACKGROUND AND OBJECTIVES: The hyperproliferative character of human cholesteatoma epithelium was confirmed through various hyperproliferation associated antibody expressions. Among the various approaches for evaluating proliferative activity, thrombomodulin (TM) is a...
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Use of Antithrombin and Thrombomodulin in the Management of Disseminated Intravascular Coagulation in Patients with Acute Cholangitis

Nakahara K, Okuse C, Adachi S, Suetani K, Kitagawa S, Okano M, Michikawa , Takagi R, Shigefuku , Itoh F

BACKGROUND/AIMS: To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS: A DIC treatment algorithm was determined on the...
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Comparison of Patency and Viability in Fresh and Cryopreserved Arterialand Venous Allograft Conduits in Dogs

Song H, Kang SK, Ryu YG, Kim YJ

  • KMID: 1491174
  • Korean J Thorac Cardiovasc Surg.
  • 2008 Apr;41(2):149-159.
BACKGROUND: With increasing coronary bypass and peripheral vascular surgeries, the demand for homologous vascular or synthetic conduits has continued to grow, but wide-spread application has been limited by dismal patency...
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Urothelial (Transitional Cell) Carcinoma Arising in Mature Cystic Teratoma: A Case Report

Lee OJ, Lee HC

  • KMID: 2277546
  • Korean J Pathol.
  • 2010 Dec;44(6):666-669.
Mature cystic teratoma (MCT) is one of the most common benign ovarian tumors, but 1-2% of MCTs are transformed to a malignant neoplasm. Urothelial carcinoma (UC) or transitional cell carcinoma...
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Viability of Endothelial Cells in Preserved Human Saphenous Vein Allografts

Chee HK, Kim YJ

  • KMID: 2062670
  • Korean J Thorac Cardiovasc Surg.
  • 2003 Apr;36(4):229-241.
BACKGROUND: Autogenous vein is the preferred vascular graft for patients who require coronary artery bypass surgery or peripheral arterial bypass surgery. When an autogenous vein is not available, an allograft...
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Cutaneous Metastasis of Transitional Cell Carcinoma of the Renal Pelvis, Clinically Mimicking an Abscess

Lee JH, Kim JE, Kang H

  • KMID: 2246406
  • Korean J Dermatol.
  • 2014 Feb;52(2):120-123.
Upper tract urothelial carcinoma (UTUC), which comprises tumors of the ureter and renal pelvis, is a rare genitourinary malignancy. Among these tumors, transitional cell carcinoma (TCC) of the renal pelvis...
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Differential Immunohistochemical Profiles for Distinguishing Prostate Carcinoma and Urothelial Carcinoma

Oh WJ, Chung AM, Kim JS, Han JH, Hong SH, Lee JY, Choi YJ

BACKGROUND: The pathologic distinction between high-grade prostate adenocarcinoma (PAC) involving the urinary bladder and high-grade urothelial carcinoma (UC) infiltrating the prostate can be difficult. However, making this distinction is clinically...
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Comparative Study of Membrane Versus Bubble Oxygenator with Relation to the Changes of Protein C System in Patients Undergoing Open Heart Surgery

Suh KP, Kim JG, Kwon KS

The protein C system is a natural anticoagulant and profibrinolytic system consisting of protein C and protein S and thrombomodulin. Because the increased fibrinolysis and the decreased activities of coagulation...
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The Role of the Coagulation and Fibrinolytic Pathway in Acute Lung Injury

Kwak SH

Acute lung injury (ALI) is a common, life-threatening cause of acute respiratory failure, which is ultimately caused by a variety of local and systemic insults. Alterations in the coagulation and...
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The Effect of Auranofin on Thrombomodulin Expression in Acute Promyelocytic Leukemia Cell

Lee IH, Jin JY, Kim MS, Kim IS

BACKGROUND: Acute promyelocytic leukemia (APL) is distinguished from other forms of leukemia by its association with bleeding diatheses. All-trans retinoic acid (ATRA) and arsenic trioxide (As2O3), which have been effectively...
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Genetic Variants of Thromobomodulin Gene as Risk Factors for Myocardial Infarction

Park HY, Kim Y, Kwon HM, Jee SH, Cho SY, Jang Y

Thrombomodulin (TM) is thrombin receptor present on the luminal surface of endothelial cells. Because the thrombin-TM complex acts as an anticoagulant, the functional variants or deficiency of TM may lead...
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The Role of Endothelial Dysfunction for Thromboembolic Risk of Patients with Atrial Fibrillation

Park HW, Yun NS, Lim SY, Lee SR, Hong S, Kim KH, Sohn IS, Hong YJ, Kim JH, Kim W, Shin MG, Ahn YK, Jeong MH, Cho JG, Park JC, Kang JC

BACKGROUND AND OBJECTIVES: Thromboembolism (TE) is a common complication of atrial fibrillation (AF). Although several serum markers for TE in AF patients have been reported, the mechanisms for TE have...
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Risk Factors for Metachronous Gastric Neoplasms in Patients Who Underwent Endoscopic Resection of a Gastric Neoplasm

Yoon H, Kim N, Shin CM, Lee HS, Kim BK, Kang GH, Kim JM, Kim JS, Lee DH, Jung HC

BACKGROUND/AIMS: To identify the risk factors for metachronous gastric neoplasms in patients who underwent an endoscopic resection of a gastric neoplasm. METHODS: We prospectively collected clinicopathologic data and measured the methylation...
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