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The Strategies for the Prevention of Chronic GVHD in Hematopoietic Stem Cell Transplantation

Lee JW

Chronic graft-versus-host disease (GVHD) is the most frequent late complication after hematopoietic cell transplantation and has a major impact on the quality of life and survival. As the pathophysiology of...
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Pancreatitis Induced by 6-mercaptopurine and 6-thioguanine in Childhood Acute Lymphoblastic Leukemia

Yoon JH, Baek JS, Kim EK, Kang HJ, Shin HY, Ahn HS

Although pancreatitis is known as a common complication during the treatment of acute lymphoblastic leukemia, acute pancreatitis that's induced by 6-mercaptopurine or 6-thioguanine is very uncommon. We experienced the case...
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A Case of Congenital Hemolytic Anemia of Unknown Cause Combined with Gilbert's Syndrome

Lim JW, Choi JH, Nam YH, Seo IS, Yoon SM, Koo MS

Congenital hemolytic anemia is mainly developed due to intrinsic defects of erythrocytes, but in some cases the cause of hemolytic anemia is unclear. Gilbert's syndrome shows mild, chronic unconjugated hyperbilirubinemia...
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Abrogation of U266 Multiple Myeloma Cell Proliferation Via Inhibition of NF-kappaB Activation by Curcumin

Park J, Ahn KS, Bae EK, Kim JH, Jung SH, Kim BS, Kim DY, Kim BK, Lee YY, Yoon SS

BACKGROUND: Curcumin is a naturally occurring biologically active compound, and it has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative properties. It is known for its anti-proliferative and proapoptotic...
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GATA1 Mutation in Transient Myeloproliferative Disorder of Down Syndrome

Ha JS, Lee WM, Kim JH, Ryoo NH, Jeon DS, Kim JR, Kim HS, Choi BK

Children with Down syndrome (DS) have a higher risk of developing leukemia than do healthy children, and they especially have a higher risk for developing transient myeloproliferative disorder (TMD) or...
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A Case of Fanconi Anemia Diagnosed by a Chromosome Breakage Test with Skin Fibroblasts

Lee JJ, Yun KB, Kim SY, Lee MJ, Jung HJ, Park JE, Kim HJ

Fanconi anemia is an autosomal recessive disease that's characterized by congenital anomalies, defective hematopoiesis and a high risk of developing acute myeloid leukemia and certain solid tumors. The clinical phenotype...
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Significance of Notch Expression in Acute Myeloid Leukemia

Cheong JW, Kim JS, Lee HW, Yoon SH, Kim SJ, Min YH

BACKGROUND: Notch is a gene family encoding receptors to transduce intercellular signals involved in cell-fate determination. Although several lines of evidence indicate that abnormal Notch signaling may contribute to neoplastic...
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Primary Isolated Bone Marrow Diffuse Large B-cell Lymphoma with Hemolytic Anemia as the First Manifestation

Lee JY, Kim JH, Shin JH, Kim HR, Lee JN, Kim KH, Lee WS, Joo YD, Sohn CH, Kim CH

Primary isolated bone marrow disease as a presenting feature of diffuse large B-cell lymphoma is very rare. We describe the first Korean case of isolated bone marrow diffuse large B-cell...
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The Usefulness of the Serum Transferrin Receptor to Serum Ferritin Ratio for Discriminating between Iron Deficiency Anemia and Anemia of Inflammation in Infants

Park ES, Kim IS, Jun JS, Seo JH, Lim JY, Park CH, Woo HO, Youn HS

BACKGROUND: The incidence of iron deficiency anaemia in infants, which is caused by the increased iron demand for rapid growth during this period, is reported to range from 10 to...
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Evaluation of the Genotypes of the Lewis Blood Group in a Korean Population Using Direct Sequencing

Song SY, An SS, Ryu SW, Kim JS, Suh IB

BACKGROUND: The FUT2 and FUT3 genes determine the Lewis phenotype of red blood cells (RBCs). Recently, the Lewis genes, the secretor genes, and several mutations that cause Lewis negative and...
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