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Treatment Outcome and Prognostic Factors for Children with Advanced Non-Hodgkin's Lymphoma at a Single Institution

Song JS, Youn HS, Im HJ, Ghim T, Moon HN, Seo JJ

BACKGROUND: Non-Hodgkin's lymphoma (NHL) accounts for over 80% of pediatric malignant lymphoma in Korea; the event free survival (EFS) of advanced stage NHL has been reported to be 60 to...
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Evans Syndrome following T Cell-repleted Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome: Successful Response to High-dose Corticosteroid

Lee YH, Kim YD, Kim YM

Evans syndrome after hematopoietic stem cell transplantation rarely occurs and this condition is refractory to treatment, particularly in childhood. We experienced a case of Evans syndrome following unmanipulated unrelated bone...
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Induction of Myeloma Cell Line-specific Cytotoxic T Lymphocytes using Monocyte-derived Dendritic Cells Pulsed with Myeloma Cell Line Lysates

Park MS, Park JS, Kang HK, Kim SK, Won JH, Choi BH, Shin SW, Zhu XW, Jin CJ, Pham TN, Cho D, Nam JH, Kim YJ, Kim YK, Yang DH, Chung IJ, Kim HJ, Lee JJ

BACKGROUND: In multiple myeloma (MM), the idiotype (ID) determinant of the paraprotein has been used for immunotherapy using dendritic cells (DCs). However, ID-specific immune responses showed limited clinical responses after...
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Reduced-intensity Umbilical Cord Blood Transplantation in Adult Acute Myeloid Leukemia: Report of Four Cases

Chong SY, Jang MJ, Kang MS, Baek JY, Chang SK, Choi YK, Oh D

The outcome after unrelated cord blood transplantation (CBT) is similar to that of matched unrelated bone marrow transplantation in children, and the results of CBT in adult patients has recently...
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A Case of Mantle Cell Lymphoma Treated with Autologous Stem Cell Transplantation and Rituximab

Oh SY, Jang MJ, Chang SK, Oh D, Chong SY

Mantle cell lymphoma is a subtype of aggressive non-Hodgkin's lymphoma and usually presents in advanced stages. When treated with a regimen such as CHOP, the median survival is about three...
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Killer Cell Immunoglobulin-like Receptor (KIR) Analysis in Adult Korean Patients with Acute Myeloid Leukemia

Kim HJ, Choi Y, Jeong HY, Min WS, Kim CC, Kim TG

BACKGROUND: The prevalent natural killer (NK) cells induce alloreaction against leukemic cells during post-transplant. NK cell alloreactivity depends on the compatibility of killer cell immunoglobulin-like receptors (KIR) epitopes for graft-versus-host...
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A Case of Catheter-related Thrombosis Treated with Local Low-dose Urokinase

Kim YB, Lee JJ, Kim SY, Kim MJ, Sul JY, Kil HR

Although indwelling central venous catheters guarantee a reliable vascular access, and are essential for the management of children undergoing anticancer chemotherapy or stem cell transplantation, these catheters may cause serious...
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A Case of Acute Lymphoblastic Leukemia in a Patient with Minimal Change Nephrotic Syndrome

Kim IY, Moon JY, Song MK, Ahn YS, Kim KY, Choi YJ, Shin HJ, Chung JS, Cho GJ

We experienced a 22-year old patient with a documented history of minimal change nephrotic syndrome (MCNS), and a diagnosis of acute lymphoblastic leukemia (ALL) was then made for this patient....
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Diagnostic Usefulness of Antibody Identification Test Including Enzyme Method

Lee DD, Oh SH, Shin HJ, Chung JS, Cho GJ, Park TS, Lee EY, Son HC, Kim HH

BACKGROUND: Many medical institutions in Korea have recently been performing an antibody screening test as one of the essential elements of a pre-transfusion test. In this study we will determine...
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Adenovirus-Mediated Antisense Vector-Induced Inhibition of Human Telomerase RNA May Induce Differentiation of CD34+ Cells

Kim SJ, Song JS, Song CH, Yoo JH, Kim BS

BACKGROUND: Background Telomerase activation and human telomerase RNA (hTR) expression are known to be related to the preservation of the "stemness" of stem cells. In this study, we have inhibited...
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A Case of Primary Breast Lymphoma with Brain Metastasis Detected during Pregnancy

Lim JY, Choi YK, Kim ES, Moon JT, Oh KK, Cho JY

Primary breast lymphoma (PBL) is a rare clinical presentation of localized non-Hodgkin's lymphoma (NHL), and it makes up 0.04~1.1% of all breast tumors and it is 0.38~0.7% of all NHLs....
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Manipulation of Human Telomerase Activity in Cancer and Stem Cells: Application of siRNA-induced Inhibition of Human Telomerase RNA (hTR)

Kim SJ, Song JS, Song CH, Yoo JH, Yoo YD, Kim JS, Kim BS

BACKGROUND: We have determined the effects of human telomerase RNA inhibiton using siRNA in tumor cells and human embryonic and mesenchymal stem cells. METHODS: We selected the sequences against the predicted...
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Vascular Complications in Patients with Essential Thrombocythemia

Nam E, Kwon JM, Lee SN, Nam SH, Lee KE, Mun YC, Seung CM, Park SH, Bang SM, Cho EK, Shin DB, Lee JH

BACKGROUND: Essential thrombocythemia (ET) has a chronic course, but its main clinical features are thrombosis and hemorrhage. We evaluated the clinical features, including the vascular complications in patients with ET,...
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