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Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus

Cho HY, Cho YM, Park MH, Kang MY, Kim KH, Ku YH, Lee EK, Park DJ, Shin CS, Park KS, Kim SY, Cho BY, Lee HK

Autoantibody negative fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at...
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Peroxisome Proliferator Activated Receptor-delta (PPAR-delta)

Choi KM

The development of novel treatments for the metabolic syndrome is imminent for decreasing the prevalence of type 2 diabetes and cardiovascular disease. Peroxisome proliferator-activated receptors (PPARs) are members of the...
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Current Status of Diabetes Management in Korea Using National Health Insurance Database

Park SW, Kim DJ, Min KW, Baik SH, Choi KM, Park IB, Park JH, Son HS, Ahn CW, Oh JY, Lee J, Chung CH, Kim J, Kim H

BACKGROUND: The prevalence of diabetes is steadily increasing in Korea. The increase in number of people with diabetes would ultimately result in premature death, poor quality of life, and increasing...
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A Case of Diabetic Ketoacidosis in Gestational Diabetes Mellitus

Kim MH, Jung ED, Hong SP, Bae GH, Ahn SY, Jeon EJ, Hong SY, Lee JH, Son HS

Gestational diabetes mellitus (GDM) is defined as glucose intolerance of variant severity with onset or first recognition during present pregnancy. Recently the prevalence of GDM in Korean has reported as...
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gamma-glutamylcysteine Synthetase (gamma-GCS) mRNA Expression in INS-1 Cells and Patients with Type 2 Diabetes Mellitus

Kim JH, Lee CH, Moon JS, Yoon JS, Won KC, Lee HW

BACKGROUND: Hyperglycemia is a well-recognized pathogenic factor of long term complications in diabetes mellitus and hyperglycemia also generates reactive oxygen species (ROS) in beta cells when ROS accumulate in excess...
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The Effect of Rosiglitazone on Gluose Metabolism and Insulin Sensitivity in Non Obese Type 2 Diabetic Rat Models

Kim MJ, Chung EJ, Ha BW, Kim JH, Nam SM, Lee MY, Kho JH, Shin YG, Chung CH

BACKGROUND: In Korea, most of type 2 diabetic patients are non obese. We made non obese type 2 diabetic rat models, which were characterized by insulin resistance and insulin secretion...
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The Correlation between Central Obesity and Glucose, Lipid Metabolism and Macrovascular Complication in Elderly Type 2 Diabetes

Jung ED, Lee J, Shon HS

BACKGROUND: Obesity is related to abnormal lipid metabolism and macrovascular complication and accumulated fat on the abdomen in elderly diabetic patients. The aim of this study was to compare elderly...
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Short-term Therapeutic Efficacy of Different Oral Hypoglycemic Agents Combined with Once Daily Insulin Glargine in Type 2 Diabetic Subjects with Failure of Sulfonylurea and Metformin Combination

Hong SI, Kim HJ, Bae JM, Song SO, Park KS, Jeon BS, Hwang SD, Choi JY, Kim JH, Kwon HJ, Choi JS, Woo ML, Cho JH, Won YJ

Backgroud: Although the extended duration of action of insulin glargine supports a convenient once daily injection, the combination with other short acting insulins or oral hypoglycemic agents is required to...
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AICAR Reversed the Glucolipotoxicity Induced beta-cell Dysfunction through Suppression of PPAR-gamma-coactivator-1 (PGC-1) Overexpression

Kwon HS, Kim JW, Park HS, Ko SH, Cha BY, Son HY, Yoon KH

BACKGROUND: Glucolipotoxicity plays an important role in the progression of type 2 diabetes mellitus via inducing insulin secretory dysfunction. Expression of insulin gene in pancreatic beta cell might be regulated...
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Transcriptional Regulation of Insulin and CXCL10 Gene by Peroxisome Proliferator Activated Receptor gamma Coactivator-1alpha

Jang WG, Lee IK, Kim EJ, Ryu SY, Kim BW, Kim JG

BACKGROUND: Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), which act as a coactivator of nuclear receptors and several other transcription factors. This study was performed to evaluate the expressional regulation of...
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In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications

Nam JS, Cho YJ, Noh TW, Kim CS, Park JS, Cho MH, Kim HJ, Yoon JE, Jung HY, Kang ES, Rhee YM, Lee HK, Ahn CW, Cha BS, Lee EJ, Lim SK, Kim KR, Lee HC

BACKGROUND: In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus...
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