- Acral Erythema and Hyperpigmentation Induced by Tegafur
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Ha SJ, Ham SH, Park YM, Cho SH, Cho BK
- KMID: 2230591
- Korean J Dermatol.
- 1998 Apr;36(2):363-366.
Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil, used in the treatment of advanced gastrointestinal neoplasms. Mucocutaneous side reactions induced by this agent are rare and include photosensitivity of lichenoid... -
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- A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL)
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Heo YS, Song HJ, Oh CH
- KMID: 2247720
- Korean J Dermatol.
- 2010 Feb;48(2):155-157.
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase,... -
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- Discoid Lupus Erythematosus-like Eruption Induced by Tegafur - Uracil (UFT)
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Yoon J, Seo SH, Kye YC, Ahn HH
- KMID: 2301813
- Korean J Dermatol.
- 2010 Nov;48(11):1004-1007.
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows... -
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- Clearance of Actinic Keratosis Caused by the Prodrug of 5-Fluorouracil
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Park IH, Hwang SM, An SK
- KMID: 1930655
- Korean J Dermatol.
- 1999 Oct;37(10):1528-1531.
Tegafur [1-(tetrahydro-2-furyl)-5-fluorouracil], the prodrug of 5-fluorouracil, is an anticancer agent. Several cutaneous reactions have been reported following systemic 5-fluorouracil for the treatment of malignancies. We report a patient with marked... -
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- Clinical Pharmacokinetics of Tegafur Administered with Epirubicin and Cisplatin in Patients with Advanced Gastric Cancer
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Kang JH, Kim YL, Cho HK, Lee ES, Cha SJ, Hong YS, Lee KS, Kuh HJ
- KMID: 2166181
- Cancer Res Treat.
- 2003 Jun;35(3):224-231.
PURPOSE: Tegafur, an oral prodrug of 5-fluorouracil (5-FU), has been used in the treatment of gastric cancers. UFT (tegafur + uracil) has been developed to enhance the efficacy of tegafur.... -
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- A Case of Achieving Complete Remission with Combination of Sorafenib and Tegafur in Patients with Hepatocellular Carcinoma with Progression of Disease after Sorafenib Therapy
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Hwang SY, Lee SM, Im JW, Jeon KJ, Ahn SB, Park JY, Choi CW, Yang KM
- KMID: 2376810
- J Liver Cancer.
- 2017 Mar;17(1):88-93.
- doi: 10.17998/jlc.17.1.88
Sorafenib is the only approved targeted agent as the first line systemic therapy for treatment of advanced hepatocellular carcinoma (HCC). However, the improvement of survival duration under 3 months is... -
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- Oral Tegafur-uracil Plus Folinic Acid versus Intravenous 5-fluorouracil Plus Folinic Acid as Adjuvant Chemotherapy of Colon Cancer
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Kim DJ, Kim TI, Suh JH, Cho YS, Shin SK, Kang JK, Kim NK, Kim WH
- KMID: 720907
- Yonsei Med J.
- 2003 Aug;44(4):665-675.
- doi: 10.3349/ymj.2003.44.4.665
To compare, in terms of compliance, toxicity, quality of life (QOL) and efficacy, intravenous 5-fluorouracil plus folinic acid with oral tegafur-uracil plus folinic acid as postoperative adjuvant chemotherapy after curative... -
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- High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer
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Sakaguchi , Motohara T, Saito F, Takaishi K, Fukumatsu , Tohya T, Shibata S, Mimori H, Tashiro H, Katabuchi
- KMID: 2160805
- J Gynecol Oncol.
- 2015 Jul;26(3):193-200.
- doi: 10.3802/jgo.2015.26.3.193
OBJECTIVE: The aim of this study was to determine the efficacy and toxicity of oral administration of tegafur-uracil (UFT) at a high dose, 600 mg/day, based on the tegafur dose,... -
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- Prospective Randomized Trial for Postoperative Adjuvant Chemotherapy in Gastric Cancer Patients without Serosal Invasion: Preliminary Report
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Kim YH, Kim BS, Lee CH, Kim WS, Yook JW, Oh ST, Park KC
- KMID: 1905552
- J Korean Gastric Cancer Assoc.
- 2001 Dec;1(4):221-227.
PURPOSE: We have carried out prospective randomized clinical trial to compare survival benefit and side effect among three postoperative adjuvant chemotherapeutic regimens in serosa-negative gastric cancer patients. MATENRIALS AND METHODS: Total... -
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- Volume-reserving Surgery after Photodynamic Therapy for Biliary Papillomatosis: A Case Report
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Cheong CO, Lim JH, Park JS, Park SW, Kim HK, Kim KS
- KMID: 2373313
- Korean J Gastroenterol.
- 2015 Jul;66(1):55-58.
- doi: 10.4166/kjg.2015.66.1.55
Biliary papillomatosis is rare, and its pathogenic mechanisms are not yet clear. Because of its high risk for malignancy transformation, surgical resection is regarded as a standard treatment. Photodynamic therapy... -
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- Oxaliplatin and UFT, leucovorin combination chemotherapy in patients with advanced colorectal cancer
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Shin JH, Kim SY, Woo CM, Kim YS, Kim JY, Seo JH, Lee WS, Bae SH, Ryoo HM, Lee HI, Shin IH, Kim MK, Lee JL, Lee KH, Hyun MS
- KMID: 2252594
- Korean J Med.
- 2004 Jul;67(1):58-64.
BACKGROUND: UFT/oral leucovorin (LV) provided a safer, more convenient oral alternative to bolus i.v. 5-Fluorouracil/LV regimen for advanced colorectal cancer while producing equivalent survival. We evaluated the efficacy and safety... -
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- S-1–Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study
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Kim N, Kim JW, Baek JH, Kim JS, Choung HK, Kim TY, Lee KH, Bang YJ, Khwarg SI, Ahn SH, Park DJ, Kim HH, Chung JY, Ahn S, Lee KW
- KMID: 2403472
- Cancer Res Treat.
- 2018 Jan;50(1):30-39.
- doi: 10.4143/crt.2016.569
PURPOSE: This prospective study was conducted to determine the incidence of lacrimal drainage obstruction (LDO) during S-1 chemotherapy and evaluate the association between the development of LDO and the concentrations... -
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- Detailed Analysis of Chromosome Aberrations in Human Leukocyte Induced by Anti-malignant Tumor Agent (FT-207)
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Hahn S, Kim DS
- KMID: 687748
- Yonsei Med J.
- 1978 Jun;19(1):7-15.
- doi: 10.3349/ymj.1978.19.1.7
The anticancer agent's FT-207, N1-(2'-tetrahydrofuryl)-5-fluorouracil, a derivative of 5FU (5-fluorouracil), induced chromosome damage to the human leukocyte was investigated. FT-207 inhibit mitosis and cause chromatid and chromosome breakage and chromatid... -
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- Recent developments in systemic chemotherapy for hepatocellular carcinoma
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Han CJ
- KMID: 1073325
- Korean J Hepatol.
- 2008 Mar;14(1):4-11.
- doi: 10.3350/kjhep.2008.14.1.4
Despite recent developments in various chemotherapeutic agents and the performing of numerous clinical trials, chemotherapy still produces unsatisfactory results in hepatocellular carcinoma due to poor clinical benefit compared with untreated... -
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- S-1 Monotherapy as a Neoadjuvant Treatment for Locally Advanced Gastric Cancer
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Jung JY, Rha SY, Ahn JB, Yang WI, Noh SH, Chung HC, Jeung HC
- KMID: 1382660
- Korean J Intern Med.
- 2008 Mar;23(1):37-41.
- doi: 10.3904/kjim.2008.23.1.37
S-1, a novel oral fluoropyrimidine, is an effective therapeutic agent for gastric cancer. Herein, we report a case with locally advanced gastric cancer that achieved a curative resection after S-1... -
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