- Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen
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Heo HR, Chen L, An B, Kim KS, Ji J, Hong SH
- KMID: 2380795
- Int J Stem Cells.
- 2015 May;8(1):18-23.
- doi: 10.15283/ijsc.2015.8.1.18
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in... -
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- Intramarrow injection of beta-catenin-activated, but not naive mesenchymal stromal cells stimulates self-renewal of hematopoietic stem cells in bone marrow
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Ahn JY, Park G, Shim JS, Lee JW, Oh IH
- KMID: 983985
- Exp Mol Med.
- 2010 Feb;42(2):122-131.
- doi: 10.3858/emm.2010.42.2.014
Bone marrow mesenchymal stromal cells (MSCs) have been implicated in the microenvironmental support of hematopoietic stem cells (HSCs) and often co-transplanted with HSCs to facilitate recovery of ablated bone marrows.... -
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- Endogenous Stem Cells in Homeostasis and Aging
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Lim JE, Son Y
- KMID: 2411864
- Tissue Eng Regen Med.
- 2017 Dec;14(6):679-698.
- doi: 10.1007/s13770-017-0097-3
In almost all human tissues and organs, adult stem cells or tissue stem cells are present in a unique location, the so-called stem cell niche or its equivalent, continuously replenishing... -
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- Minimal Requirement of Limbal Epithelium for Successful Limbal Cell Transplantation in Rabbit Corneas
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Yang YR, Choi NY, Kim JH, Kim MS
- KMID: 2337329
- J Korean Ophthalmol Soc.
- 2006 Apr;47(4):613-620.
PURPOSE: To investigate the minimal requirements of the limbal epithelium for successful limbal stem cell transplantation and the healing process. METHODS: Nine rabbits were divided into 4, 6, and 8 clock-hour... -
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- Mesenchymal stromal cells in myeloid malignancies
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Schroeder , Geyh S, Germing U, Haas R
- KMID: 2364312
- Blood Res.
- 2016 Dec;51(4):225-232.
- doi: 10.5045/br.2016.51.4.225
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal myeloid disorders characterized by hematopoietic insufficiency. As MDS and AML are considered to originate from genetic and molecular defects of... -
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- The Efficacy and Safety of Collagen-I and Hypoxic Conditions in Urine-Derived Stem Cell Ex Vivo Culture
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Chun SY, Kim HT, Kwon SY, Kim J, Kim BS, Yoo ES, Kwon TG
- KMID: 2382940
- Tissue Eng Regen Med.
- 2016 Aug;13(4):403-415.
- doi: 10.1007/s13770-016-9073-6
Upper urinary tract-derived urine stem cells (USCs) are considered a valuable mesenchymal stem cell source for autologous cell therapy. However, the reported culture condition for USCs is not appropriate for... -
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- Tracking the Fate of Muscle-derived Stem Cells: an Insight into the Distribution and Mode of Action
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Park HS, Choi GH, Hahn S, Yoo YS, Jung IM, Lee T
- KMID: 2319514
- Vasc Spec Int.
- 2014 Mar;30(1):11-18.
PURPOSE: To examine the fate of muscle-derived stem cells (MDSC) after injection into different host conditions and provide an insight for their mechanism of action. MATERIALS AND METHODS: MDSCs differentiated in... -
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- Hypoxia Enhances Cell Properties of Human Mesenchymal Stem Cells
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Kwon SY, Chun SY, Ha YS, Kim DH, Kim J, Song PH, Kim HT, Yoo ES, Kim BS, Kwon TG
- KMID: 2394993
- Tissue Eng Regen Med.
- 2017 Oct;14(5):595-604.
- doi: 10.1007/s13770-017-0068-8
Atmospheric (in vitro) oxygen pressure is around 150 mm Hg (20% O₂), whereas physiologic (in vivo) oxygen pressure ranges between 5 and 50 mm Hg (0.7–7% O₂). The normoxic environment... -
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- Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
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Kobet RA, Pan X, Zhang B, Pak SC, Asch AS, Lee MH
- KMID: 2380313
- Biomol Ther.
- 2014 Sep;22(5):371-383.
- doi: 10.4062/biomolther.2014.084
The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional... -
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- Long-Duration Three-Dimensional Spheroid Culture Promotes Angiogenic Activities of Adipose-Derived Mesenchymal Stem Cells
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Lee JH, Han YS, Lee SH
- KMID: 2164218
- Biomol Ther.
- 2016 May;24(3):260-267.
- doi: 10.4062/biomolther.2015.146
Mesenchymal stem cells (MSCs) offer significant therapeutic promise for various regenerative therapies. However, MSC-based therapy for injury exhibits low efficacy due to the pathological environment in target tissues and the... -
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